FeCl(3)∙6H(2)O/TMSBr-Catalyzed Rapid Synthesis of Dihydropyrimidinones and Dihydropyrimidinethiones under Microwave Irradiation

An efficient and practical protocol has been developed to synthesize dihydropyrimidinones and dihydropyrimidinethiones through FeCl(3)∙6H(2)O/TMSBr-catalyzed three-component cyclocondensation under microwave irradiation. This approach features high yields, broad substrate scope, short reaction time,...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Fei, Jia, Xiuwen, Li, Pinyi, Zhao, Jingwei, Huang, Jun, Li, Honglian, Li, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151402/
https://www.ncbi.nlm.nih.gov/pubmed/28892005
http://dx.doi.org/10.3390/molecules22091503
_version_ 1783357144996773888
author Zhao, Fei
Jia, Xiuwen
Li, Pinyi
Zhao, Jingwei
Huang, Jun
Li, Honglian
Li, Lin
author_facet Zhao, Fei
Jia, Xiuwen
Li, Pinyi
Zhao, Jingwei
Huang, Jun
Li, Honglian
Li, Lin
author_sort Zhao, Fei
collection PubMed
description An efficient and practical protocol has been developed to synthesize dihydropyrimidinones and dihydropyrimidinethiones through FeCl(3)∙6H(2)O/TMSBr-catalyzed three-component cyclocondensation under microwave irradiation. This approach features high yields, broad substrate scope, short reaction time, mild reaction conditions, operational simplicity and easy work-up, thus affording a versatile method for the synthesis of dihydropyrimidinones and dihydropyrimidinethiones.
format Online
Article
Text
id pubmed-6151402
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-61514022018-11-13 FeCl(3)∙6H(2)O/TMSBr-Catalyzed Rapid Synthesis of Dihydropyrimidinones and Dihydropyrimidinethiones under Microwave Irradiation Zhao, Fei Jia, Xiuwen Li, Pinyi Zhao, Jingwei Huang, Jun Li, Honglian Li, Lin Molecules Article An efficient and practical protocol has been developed to synthesize dihydropyrimidinones and dihydropyrimidinethiones through FeCl(3)∙6H(2)O/TMSBr-catalyzed three-component cyclocondensation under microwave irradiation. This approach features high yields, broad substrate scope, short reaction time, mild reaction conditions, operational simplicity and easy work-up, thus affording a versatile method for the synthesis of dihydropyrimidinones and dihydropyrimidinethiones. MDPI 2017-09-11 /pmc/articles/PMC6151402/ /pubmed/28892005 http://dx.doi.org/10.3390/molecules22091503 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhao, Fei
Jia, Xiuwen
Li, Pinyi
Zhao, Jingwei
Huang, Jun
Li, Honglian
Li, Lin
FeCl(3)∙6H(2)O/TMSBr-Catalyzed Rapid Synthesis of Dihydropyrimidinones and Dihydropyrimidinethiones under Microwave Irradiation
title FeCl(3)∙6H(2)O/TMSBr-Catalyzed Rapid Synthesis of Dihydropyrimidinones and Dihydropyrimidinethiones under Microwave Irradiation
title_full FeCl(3)∙6H(2)O/TMSBr-Catalyzed Rapid Synthesis of Dihydropyrimidinones and Dihydropyrimidinethiones under Microwave Irradiation
title_fullStr FeCl(3)∙6H(2)O/TMSBr-Catalyzed Rapid Synthesis of Dihydropyrimidinones and Dihydropyrimidinethiones under Microwave Irradiation
title_full_unstemmed FeCl(3)∙6H(2)O/TMSBr-Catalyzed Rapid Synthesis of Dihydropyrimidinones and Dihydropyrimidinethiones under Microwave Irradiation
title_short FeCl(3)∙6H(2)O/TMSBr-Catalyzed Rapid Synthesis of Dihydropyrimidinones and Dihydropyrimidinethiones under Microwave Irradiation
title_sort fecl(3)∙6h(2)o/tmsbr-catalyzed rapid synthesis of dihydropyrimidinones and dihydropyrimidinethiones under microwave irradiation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151402/
https://www.ncbi.nlm.nih.gov/pubmed/28892005
http://dx.doi.org/10.3390/molecules22091503
work_keys_str_mv AT zhaofei fecl36h2otmsbrcatalyzedrapidsynthesisofdihydropyrimidinonesanddihydropyrimidinethionesundermicrowaveirradiation
AT jiaxiuwen fecl36h2otmsbrcatalyzedrapidsynthesisofdihydropyrimidinonesanddihydropyrimidinethionesundermicrowaveirradiation
AT lipinyi fecl36h2otmsbrcatalyzedrapidsynthesisofdihydropyrimidinonesanddihydropyrimidinethionesundermicrowaveirradiation
AT zhaojingwei fecl36h2otmsbrcatalyzedrapidsynthesisofdihydropyrimidinonesanddihydropyrimidinethionesundermicrowaveirradiation
AT huangjun fecl36h2otmsbrcatalyzedrapidsynthesisofdihydropyrimidinonesanddihydropyrimidinethionesundermicrowaveirradiation
AT lihonglian fecl36h2otmsbrcatalyzedrapidsynthesisofdihydropyrimidinonesanddihydropyrimidinethionesundermicrowaveirradiation
AT lilin fecl36h2otmsbrcatalyzedrapidsynthesisofdihydropyrimidinonesanddihydropyrimidinethionesundermicrowaveirradiation

Ejemplares similares