Solvent-Free Synthesis and Safener Activity of Sulfonylurea Benzothiazolines

A series of novel sulfonylurea benzothiazolines was designed by splicing active groups and bioisosterism. A solvent-free synthetic route was developed for the sulfonylurea benzothiazoline derivatives via the cyclization and carbamylation. All compounds were characterized by IR, (1)H-NMR, (13)C-NMR,...

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Detalles Bibliográficos
Autores principales: Fu, Ying, Wang, Jing-Yi, Zhang, Dong, Chen, Yu-Feng, Gao, Shuang, Zhao, Li-Xia, Ye, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151413/
https://www.ncbi.nlm.nih.gov/pubmed/28937640
http://dx.doi.org/10.3390/molecules22101601
Descripción
Sumario:A series of novel sulfonylurea benzothiazolines was designed by splicing active groups and bioisosterism. A solvent-free synthetic route was developed for the sulfonylurea benzothiazoline derivatives via the cyclization and carbamylation. All compounds were characterized by IR, (1)H-NMR, (13)C-NMR, HRMS. The biological activity tests indicated the compounds could protect maize against the injury caused by chlorsulfuron to some extent. The molecular docking result showed that the new compound competed with chlorsulfuron to bind with the herbicide target enzyme active site to attain detoxification.

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