Solvent-Free Synthesis and Safener Activity of Sulfonylurea Benzothiazolines

A series of novel sulfonylurea benzothiazolines was designed by splicing active groups and bioisosterism. A solvent-free synthetic route was developed for the sulfonylurea benzothiazoline derivatives via the cyclization and carbamylation. All compounds were characterized by IR, (1)H-NMR, (13)C-NMR,...

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Detalles Bibliográficos
Autores principales: Fu, Ying, Wang, Jing-Yi, Zhang, Dong, Chen, Yu-Feng, Gao, Shuang, Zhao, Li-Xia, Ye, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151413/
https://www.ncbi.nlm.nih.gov/pubmed/28937640
http://dx.doi.org/10.3390/molecules22101601
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author Fu, Ying
Wang, Jing-Yi
Zhang, Dong
Chen, Yu-Feng
Gao, Shuang
Zhao, Li-Xia
Ye, Fei
author_facet Fu, Ying
Wang, Jing-Yi
Zhang, Dong
Chen, Yu-Feng
Gao, Shuang
Zhao, Li-Xia
Ye, Fei
author_sort Fu, Ying
collection PubMed
description A series of novel sulfonylurea benzothiazolines was designed by splicing active groups and bioisosterism. A solvent-free synthetic route was developed for the sulfonylurea benzothiazoline derivatives via the cyclization and carbamylation. All compounds were characterized by IR, (1)H-NMR, (13)C-NMR, HRMS. The biological activity tests indicated the compounds could protect maize against the injury caused by chlorsulfuron to some extent. The molecular docking result showed that the new compound competed with chlorsulfuron to bind with the herbicide target enzyme active site to attain detoxification.
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spelling pubmed-61514132018-11-13 Solvent-Free Synthesis and Safener Activity of Sulfonylurea Benzothiazolines Fu, Ying Wang, Jing-Yi Zhang, Dong Chen, Yu-Feng Gao, Shuang Zhao, Li-Xia Ye, Fei Molecules Article A series of novel sulfonylurea benzothiazolines was designed by splicing active groups and bioisosterism. A solvent-free synthetic route was developed for the sulfonylurea benzothiazoline derivatives via the cyclization and carbamylation. All compounds were characterized by IR, (1)H-NMR, (13)C-NMR, HRMS. The biological activity tests indicated the compounds could protect maize against the injury caused by chlorsulfuron to some extent. The molecular docking result showed that the new compound competed with chlorsulfuron to bind with the herbicide target enzyme active site to attain detoxification. MDPI 2017-09-22 /pmc/articles/PMC6151413/ /pubmed/28937640 http://dx.doi.org/10.3390/molecules22101601 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fu, Ying
Wang, Jing-Yi
Zhang, Dong
Chen, Yu-Feng
Gao, Shuang
Zhao, Li-Xia
Ye, Fei
Solvent-Free Synthesis and Safener Activity of Sulfonylurea Benzothiazolines
title Solvent-Free Synthesis and Safener Activity of Sulfonylurea Benzothiazolines
title_full Solvent-Free Synthesis and Safener Activity of Sulfonylurea Benzothiazolines
title_fullStr Solvent-Free Synthesis and Safener Activity of Sulfonylurea Benzothiazolines
title_full_unstemmed Solvent-Free Synthesis and Safener Activity of Sulfonylurea Benzothiazolines
title_short Solvent-Free Synthesis and Safener Activity of Sulfonylurea Benzothiazolines
title_sort solvent-free synthesis and safener activity of sulfonylurea benzothiazolines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151413/
https://www.ncbi.nlm.nih.gov/pubmed/28937640
http://dx.doi.org/10.3390/molecules22101601
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