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Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818

Plant endophytic microorganisms represent a largely untapped resource for new bioactive natural products. Eight polyketide natural products were isolated from a mangrove endophytic fungus Phomosis sp. A818. The structural elucidation of these compounds revealed that they share a distinct feature in...

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Detalles Bibliográficos
Autores principales: Zhang, Wei, Zhao, Baobing, Du, Liangcheng, Shen, Yuemao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151419/
https://www.ncbi.nlm.nih.gov/pubmed/28906443
http://dx.doi.org/10.3390/molecules22091547
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author Zhang, Wei
Zhao, Baobing
Du, Liangcheng
Shen, Yuemao
author_facet Zhang, Wei
Zhao, Baobing
Du, Liangcheng
Shen, Yuemao
author_sort Zhang, Wei
collection PubMed
description Plant endophytic microorganisms represent a largely untapped resource for new bioactive natural products. Eight polyketide natural products were isolated from a mangrove endophytic fungus Phomosis sp. A818. The structural elucidation of these compounds revealed that they share a distinct feature in their chemical structures, an oxygen-bridged cyclooctadiene core skeleton. The study on their structure–activity relationship showed that the α,β-unsaturated δ-lactone moiety, as exemplified in compounds 1 and 2, was critical to the cytotoxic activity of these compounds. In addition, compound 4 might be a potential agonist of AMPK (5′-adenosine monophosphate-activated protein kinase).
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spelling pubmed-61514192018-11-13 Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818 Zhang, Wei Zhao, Baobing Du, Liangcheng Shen, Yuemao Molecules Article Plant endophytic microorganisms represent a largely untapped resource for new bioactive natural products. Eight polyketide natural products were isolated from a mangrove endophytic fungus Phomosis sp. A818. The structural elucidation of these compounds revealed that they share a distinct feature in their chemical structures, an oxygen-bridged cyclooctadiene core skeleton. The study on their structure–activity relationship showed that the α,β-unsaturated δ-lactone moiety, as exemplified in compounds 1 and 2, was critical to the cytotoxic activity of these compounds. In addition, compound 4 might be a potential agonist of AMPK (5′-adenosine monophosphate-activated protein kinase). MDPI 2017-09-14 /pmc/articles/PMC6151419/ /pubmed/28906443 http://dx.doi.org/10.3390/molecules22091547 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Wei
Zhao, Baobing
Du, Liangcheng
Shen, Yuemao
Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818
title Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818
title_full Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818
title_fullStr Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818
title_full_unstemmed Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818
title_short Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818
title_sort cytotoxic polyketides with an oxygen-bridged cyclooctadiene core skeleton from the mangrove endophytic fungus phomosis sp. a818
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151419/
https://www.ncbi.nlm.nih.gov/pubmed/28906443
http://dx.doi.org/10.3390/molecules22091547
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