Cargando…
Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818
Plant endophytic microorganisms represent a largely untapped resource for new bioactive natural products. Eight polyketide natural products were isolated from a mangrove endophytic fungus Phomosis sp. A818. The structural elucidation of these compounds revealed that they share a distinct feature in...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151419/ https://www.ncbi.nlm.nih.gov/pubmed/28906443 http://dx.doi.org/10.3390/molecules22091547 |
_version_ | 1783357149023305728 |
---|---|
author | Zhang, Wei Zhao, Baobing Du, Liangcheng Shen, Yuemao |
author_facet | Zhang, Wei Zhao, Baobing Du, Liangcheng Shen, Yuemao |
author_sort | Zhang, Wei |
collection | PubMed |
description | Plant endophytic microorganisms represent a largely untapped resource for new bioactive natural products. Eight polyketide natural products were isolated from a mangrove endophytic fungus Phomosis sp. A818. The structural elucidation of these compounds revealed that they share a distinct feature in their chemical structures, an oxygen-bridged cyclooctadiene core skeleton. The study on their structure–activity relationship showed that the α,β-unsaturated δ-lactone moiety, as exemplified in compounds 1 and 2, was critical to the cytotoxic activity of these compounds. In addition, compound 4 might be a potential agonist of AMPK (5′-adenosine monophosphate-activated protein kinase). |
format | Online Article Text |
id | pubmed-6151419 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61514192018-11-13 Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818 Zhang, Wei Zhao, Baobing Du, Liangcheng Shen, Yuemao Molecules Article Plant endophytic microorganisms represent a largely untapped resource for new bioactive natural products. Eight polyketide natural products were isolated from a mangrove endophytic fungus Phomosis sp. A818. The structural elucidation of these compounds revealed that they share a distinct feature in their chemical structures, an oxygen-bridged cyclooctadiene core skeleton. The study on their structure–activity relationship showed that the α,β-unsaturated δ-lactone moiety, as exemplified in compounds 1 and 2, was critical to the cytotoxic activity of these compounds. In addition, compound 4 might be a potential agonist of AMPK (5′-adenosine monophosphate-activated protein kinase). MDPI 2017-09-14 /pmc/articles/PMC6151419/ /pubmed/28906443 http://dx.doi.org/10.3390/molecules22091547 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhang, Wei Zhao, Baobing Du, Liangcheng Shen, Yuemao Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818 |
title | Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818 |
title_full | Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818 |
title_fullStr | Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818 |
title_full_unstemmed | Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818 |
title_short | Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818 |
title_sort | cytotoxic polyketides with an oxygen-bridged cyclooctadiene core skeleton from the mangrove endophytic fungus phomosis sp. a818 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151419/ https://www.ncbi.nlm.nih.gov/pubmed/28906443 http://dx.doi.org/10.3390/molecules22091547 |
work_keys_str_mv | AT zhangwei cytotoxicpolyketideswithanoxygenbridgedcyclooctadienecoreskeletonfromthemangroveendophyticfungusphomosisspa818 AT zhaobaobing cytotoxicpolyketideswithanoxygenbridgedcyclooctadienecoreskeletonfromthemangroveendophyticfungusphomosisspa818 AT duliangcheng cytotoxicpolyketideswithanoxygenbridgedcyclooctadienecoreskeletonfromthemangroveendophyticfungusphomosisspa818 AT shenyuemao cytotoxicpolyketideswithanoxygenbridgedcyclooctadienecoreskeletonfromthemangroveendophyticfungusphomosisspa818 |