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Phytotherapeutics: The Emerging Role of Intestinal and Hepatocellular Transporters in Drug Interactions with Botanical Supplements

In herbalism, botanical supplements are commonly believed to be safe remedies, however, botanical supplements and dietary ingredients interact with transport and metabolic processes, affecting drug disposition. Although a large number of studies have described that botanical supplements interfere wi...

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Autores principales: Murtaza, Ghulam, Ullah, Naveed, Mukhtar, Farah, Nawazish, Shamyla, Muneer, Saiqa, Mariam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151444/
https://www.ncbi.nlm.nih.gov/pubmed/29065448
http://dx.doi.org/10.3390/molecules22101699
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author Murtaza, Ghulam
Ullah, Naveed
Mukhtar, Farah
Nawazish, Shamyla
Muneer, Saiqa
Mariam,
author_facet Murtaza, Ghulam
Ullah, Naveed
Mukhtar, Farah
Nawazish, Shamyla
Muneer, Saiqa
Mariam,
author_sort Murtaza, Ghulam
collection PubMed
description In herbalism, botanical supplements are commonly believed to be safe remedies, however, botanical supplements and dietary ingredients interact with transport and metabolic processes, affecting drug disposition. Although a large number of studies have described that botanical supplements interfere with drug metabolism, the mode of their interaction with drug transport processes is not well described. Such interactions may result in serious undesired effects and changed drug efficacy, therefore, some studies on interaction between botanical supplement ingredients and drug transporters such as P-gp and OATPs are described here, suggesting that the interaction between botanical supplements and the drug transporters is clinically significant.
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spelling pubmed-61514442018-11-13 Phytotherapeutics: The Emerging Role of Intestinal and Hepatocellular Transporters in Drug Interactions with Botanical Supplements Murtaza, Ghulam Ullah, Naveed Mukhtar, Farah Nawazish, Shamyla Muneer, Saiqa Mariam, Molecules Review In herbalism, botanical supplements are commonly believed to be safe remedies, however, botanical supplements and dietary ingredients interact with transport and metabolic processes, affecting drug disposition. Although a large number of studies have described that botanical supplements interfere with drug metabolism, the mode of their interaction with drug transport processes is not well described. Such interactions may result in serious undesired effects and changed drug efficacy, therefore, some studies on interaction between botanical supplement ingredients and drug transporters such as P-gp and OATPs are described here, suggesting that the interaction between botanical supplements and the drug transporters is clinically significant. MDPI 2017-10-21 /pmc/articles/PMC6151444/ /pubmed/29065448 http://dx.doi.org/10.3390/molecules22101699 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Murtaza, Ghulam
Ullah, Naveed
Mukhtar, Farah
Nawazish, Shamyla
Muneer, Saiqa
Mariam,
Phytotherapeutics: The Emerging Role of Intestinal and Hepatocellular Transporters in Drug Interactions with Botanical Supplements
title Phytotherapeutics: The Emerging Role of Intestinal and Hepatocellular Transporters in Drug Interactions with Botanical Supplements
title_full Phytotherapeutics: The Emerging Role of Intestinal and Hepatocellular Transporters in Drug Interactions with Botanical Supplements
title_fullStr Phytotherapeutics: The Emerging Role of Intestinal and Hepatocellular Transporters in Drug Interactions with Botanical Supplements
title_full_unstemmed Phytotherapeutics: The Emerging Role of Intestinal and Hepatocellular Transporters in Drug Interactions with Botanical Supplements
title_short Phytotherapeutics: The Emerging Role of Intestinal and Hepatocellular Transporters in Drug Interactions with Botanical Supplements
title_sort phytotherapeutics: the emerging role of intestinal and hepatocellular transporters in drug interactions with botanical supplements
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151444/
https://www.ncbi.nlm.nih.gov/pubmed/29065448
http://dx.doi.org/10.3390/molecules22101699
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