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Phytotherapeutics: The Emerging Role of Intestinal and Hepatocellular Transporters in Drug Interactions with Botanical Supplements
In herbalism, botanical supplements are commonly believed to be safe remedies, however, botanical supplements and dietary ingredients interact with transport and metabolic processes, affecting drug disposition. Although a large number of studies have described that botanical supplements interfere wi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151444/ https://www.ncbi.nlm.nih.gov/pubmed/29065448 http://dx.doi.org/10.3390/molecules22101699 |
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author | Murtaza, Ghulam Ullah, Naveed Mukhtar, Farah Nawazish, Shamyla Muneer, Saiqa Mariam, |
author_facet | Murtaza, Ghulam Ullah, Naveed Mukhtar, Farah Nawazish, Shamyla Muneer, Saiqa Mariam, |
author_sort | Murtaza, Ghulam |
collection | PubMed |
description | In herbalism, botanical supplements are commonly believed to be safe remedies, however, botanical supplements and dietary ingredients interact with transport and metabolic processes, affecting drug disposition. Although a large number of studies have described that botanical supplements interfere with drug metabolism, the mode of their interaction with drug transport processes is not well described. Such interactions may result in serious undesired effects and changed drug efficacy, therefore, some studies on interaction between botanical supplement ingredients and drug transporters such as P-gp and OATPs are described here, suggesting that the interaction between botanical supplements and the drug transporters is clinically significant. |
format | Online Article Text |
id | pubmed-6151444 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61514442018-11-13 Phytotherapeutics: The Emerging Role of Intestinal and Hepatocellular Transporters in Drug Interactions with Botanical Supplements Murtaza, Ghulam Ullah, Naveed Mukhtar, Farah Nawazish, Shamyla Muneer, Saiqa Mariam, Molecules Review In herbalism, botanical supplements are commonly believed to be safe remedies, however, botanical supplements and dietary ingredients interact with transport and metabolic processes, affecting drug disposition. Although a large number of studies have described that botanical supplements interfere with drug metabolism, the mode of their interaction with drug transport processes is not well described. Such interactions may result in serious undesired effects and changed drug efficacy, therefore, some studies on interaction between botanical supplement ingredients and drug transporters such as P-gp and OATPs are described here, suggesting that the interaction between botanical supplements and the drug transporters is clinically significant. MDPI 2017-10-21 /pmc/articles/PMC6151444/ /pubmed/29065448 http://dx.doi.org/10.3390/molecules22101699 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Murtaza, Ghulam Ullah, Naveed Mukhtar, Farah Nawazish, Shamyla Muneer, Saiqa Mariam, Phytotherapeutics: The Emerging Role of Intestinal and Hepatocellular Transporters in Drug Interactions with Botanical Supplements |
title | Phytotherapeutics: The Emerging Role of Intestinal and Hepatocellular Transporters in Drug Interactions with Botanical Supplements |
title_full | Phytotherapeutics: The Emerging Role of Intestinal and Hepatocellular Transporters in Drug Interactions with Botanical Supplements |
title_fullStr | Phytotherapeutics: The Emerging Role of Intestinal and Hepatocellular Transporters in Drug Interactions with Botanical Supplements |
title_full_unstemmed | Phytotherapeutics: The Emerging Role of Intestinal and Hepatocellular Transporters in Drug Interactions with Botanical Supplements |
title_short | Phytotherapeutics: The Emerging Role of Intestinal and Hepatocellular Transporters in Drug Interactions with Botanical Supplements |
title_sort | phytotherapeutics: the emerging role of intestinal and hepatocellular transporters in drug interactions with botanical supplements |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151444/ https://www.ncbi.nlm.nih.gov/pubmed/29065448 http://dx.doi.org/10.3390/molecules22101699 |
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