Targeting PDE10A GAF Domain with Small Molecules: A Way for Allosteric Modulation with Anti-Inflammatory Effects

Phosphodiesterase (PDE) enzymes regulate the levels of cyclic nucleotides, cAMP, and/or cGMP, being attractive therapeutic targets. In order to modulate PDE activity in a selective way, we focused our efforts on the search of allosteric modulators. Based on the crystal structure of the PDE10A GAF-B...

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Detalles Bibliográficos
Autores principales: García, Ana M., Brea, José, González-García, Alejandro, Pérez, Concepción, Cadavid, María Isabel, Loza, María Isabel, Martinez, Ana, Gil, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151459/
https://www.ncbi.nlm.nih.gov/pubmed/28869560
http://dx.doi.org/10.3390/molecules22091472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151459/
https://www.ncbi.nlm.nih.gov/pubmed/28869560
http://dx.doi.org/10.3390/molecules22091472

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