Cargando…

Design, Synthesis, Antimycobacterial Evaluation, and In Silico Studies of 3-(Phenylcarbamoyl)-pyrazine-2-carboxylic Acids

Pyrazinamide, the first-line antitubercular drug, has been regarded the basic component of tuberculosis treatment for over sixty years. Researchers have investigated its effect on Mycobacterium tuberculosis for this long time, and as a result, new potential targets of pyrazinamide or its active form...

Descripción completa

Detalles Bibliográficos
Autores principales:	Semelková, Lucia, Janošcová, Petra, Fernandes, Carlos, Bouz, Ghada, Janďourek, Ondřej, Konečná, Klára, Paterová, Pavla, Navrátilová, Lucie, Kuneš, Jiří, Doležal, Martin, Zitko, Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151461/ https://www.ncbi.nlm.nih.gov/pubmed/28880230 http://dx.doi.org/10.3390/molecules22091491

Ejemplares similares

3-Substituted N-Benzylpyrazine-2-carboxamide Derivatives: Synthesis, Antimycobacterial and Antibacterial Evaluation
por: Semelková, Lucia, et al.
Publicado: (2017)

Derivatives of 3-Aminopyrazine-2-carboxamides: Synthesis, Antimicrobial Evaluation, and in Vitro Cytotoxicity
por: Bouz, Ghada, et al.
Publicado: (2019)

Design, Synthesis and Evaluation of N-pyrazinylbenzamides as Potential Antimycobacterial Agents
por: Zitko, Jan, et al.
Publicado: (2018)

N-Pyrazinoyl Substituted Amino Acids as Potential Antimycobacterial Agents—the Synthesis and Biological Evaluation of Enantiomers
por: Juhás, Martin, et al.
Publicado: (2020)

Substituted N-(Pyrazin-2-yl)benzenesulfonamides; Synthesis, Anti-Infective Evaluation, Cytotoxicity, and In Silico Studies
por: Bouz, Ghada, et al.
Publicado: (2019)

Synthesis and Biological Evaluation of N-Alkyl-3-(alkylamino)-pyrazine-2-carboxamides
por: Semelkova, Lucia, et al.
Publicado: (2015)

5-Alkylamino-N-phenylpyrazine-2-carboxamides: Design, Preparation, and Antimycobacterial Evaluation
por: Ambrożkiewicz, Weronika, et al.
Publicado: (2020)

Synthesis of Novel Pyrazinamide Derivatives Based on 3-Chloropyrazine-2-carboxamide and Their Antimicrobial Evaluation
por: Jandourek, Ondrej, et al.
Publicado: (2017)

Adenosine-Mimicking Derivatives of 3-Aminopyrazine-2-Carboxamide: Towards Inhibitors of Prolyl-tRNA Synthetase with Antimycobacterial Activity
por: Pallabothula, Vinod Sukanth Kumar, et al.
Publicado: (2022)

Novel Halogenated Pyrazine-Based Chalcones as Potential Antimicrobial Drugs †
por: Kucerova-Chlupacova, Marta, et al.
Publicado: (2016)

Synthesis, Biological Evaluation, and In Silico Modeling of N-Substituted Quinoxaline-2-Carboxamides
por: Bouz, Ghada, et al.
Publicado: (2021)

Synthesis, Antimycobacterial Activity and In Vitro Cytotoxicity of 5-Chloro-N-phenylpyrazine-2-carboxamides
por: Zitko, Jan, et al.
Publicado: (2013)

Ureidopyrazine Derivatives: Synthesis and Biological Evaluation as Anti-Infectives and Abiotic Elicitors
por: Bouz, Ghada, et al.
Publicado: (2017)

New Potentially Active Pyrazinamide Derivatives Synthesized Under Microwave Conditions
por: Jandourek, Ondrej, et al.
Publicado: (2014)

Design, Synthesis and Antimicrobial Evaluation of New N-(1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)(hetero)aryl-2-carboxamides as Potential Inhibitors of Mycobacterial Leucyl-tRNA Synthetase
por: Šlechta, Petr, et al.
Publicado: (2023)

Semisynthetic Derivatives of Selected Amaryllidaceae Alkaloids as a New Class of Antimycobacterial Agents
por: Maafi, Negar, et al.
Publicado: (2021)

Substituted N-Phenylpyrazine-2-carboxamides: Synthesis and Antimycobacterial Evaluation
por: Doležal, Martin, et al.
Publicado: (2009)

Alkaloids of Dicranostigma franchetianum (Papaveraceae) and Berberine Derivatives as a New Class of Antimycobacterial Agents
por: Wijaya, Viriyanata, et al.
Publicado: (2022)

Novel Pyrazine Analogs of Chalcones: Synthesis and Evaluation of Their Antifungal and Antimycobacterial Activity
por: Kucerova-Chlupacova, Marta, et al.
Publicado: (2015)

Substituted Amides of Pyrazine-2-carboxylic acids: Synthesis and Biological Activity.
por: Dolezal, Martin, et al.
Publicado: (2002)

N-Substituted 5-Amino-6-methylpyrazine-2,3-dicarbonitriles: Microwave-Assisted Synthesis and Biological Properties
por: Jandourek, Ondrej, et al.
Publicado: (2014)

Diethyl 2-(Phenylcarbamoyl)phenyl Phosphorothioates: Synthesis, Antimycobacterial Activity and Cholinesterase Inhibition
por: Vinšová, Jarmila, et al.
Publicado: (2014)

Synthesis, Antimycobacterial, Antifungal and Photosynthesis-Inhibiting Activity of Chlorinated N-phenylpyrazine-2-carboxamides †
por: Dolezal, Martin, et al.
Publicado: (2010)

Improving Antimicrobial Activity and Physico-Chemical Properties by Isosteric Replacement of 2-Aminothiazole with 2-Aminooxazole
por: Juhás, Martin, et al.
Publicado: (2022)

Correction: Juhás et al. Improving Antimicrobial Activity and Physico-Chemical Properties by Isosteric Replacement of 2-Aminothiazole with 2-Aminooxazole. Pharmaceuticals 2022, 15, 580
por: Juhás, Martin, et al.
Publicado: (2023)

Comprehensive insight into anti-staphylococcal and anti-enterococcal action of brominated and chlorinated pyrazine-based chalcones
por: Konečná, Klára, et al.
Publicado: (2022)

3-(Phenylcarbamoyl)acrylic acid
por: Jin, Shouwen, et al.
Publicado: (2012)

(S)-Benzyl 3-phenylcarbamoyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate
por: Naicker, Tricia, et al.
Publicado: (2012)

4-Aminobenzoic Acid Derivatives: Converting Folate Precursor to Antimicrobial and Cytotoxic Agents
por: Krátký, Martin, et al.
Publicado: (2019)

Methyl pyrazine-2-carboxylate
por: Zhang, Chang-Hua, et al.
Publicado: (2009)

Bis(N-methyl-N-phenylcarbamoyl)disulfane
por: Schroll, Alayne L., et al.
Publicado: (2012)

Disorder in the anionic part of catena-poly[[(pyrazine-2-carboxylato)copper(II)]-μ-pyrazine-2-carboxylato]
por: Albanez, Joselyn, et al.
Publicado: (2012)

catena-Poly[[[bis(3-aminopyrazine-2-carboxylato)triaquapraseodymium(III)]-μ-3-aminopyrazine-2-carboxylato-[(3-aminopyrazine-2-carboxylato)diaquaformatopraseodymium(III)]-μ-3-aminopyrazine-2-carboxylato] hexahydrate]
por: Gao, Shan, et al.
Publicado: (2011)

2-[(Phenylcarbamoyl)amino]butyl N-phenylcarbamate
por: Mohamed, Shaaban K., et al.
Publicado: (2012)

Ammonium 2-aminopyrazine-3-carboxylate
por: Lutz, Martin, et al.
Publicado: (2011)

Poly[[hepta-μ(2)-aqua-bis(μ(2)-pyrazine-2-carboxylato)dibarium] bis(pyrazine-2-carboxylate)]
por: Shuai, Qi, et al.
Publicado: (2011)

Advances in Antifungal Drug Development: An Up-To-Date Mini Review
por: Bouz, Ghada, et al.
Publicado: (2021)

catena-Poly[[[diaquanickel(II)]-μ-pyrazine-2-carboxylato-silver(I)-μ-pyrazine-2-carboxylato] nitrate dihydrate]
por: Yang, Min, et al.
Publicado: (2012)

Acridinium 3-carboxypyrazine-2-carboxylate
por: Attar Gharamaleki, Jafar, et al.
Publicado: (2010)

Risk Factors for Infections, Antibiotic Therapy, and Its Impact on Cancer Therapy Outcomes for Patients with Solid Tumors
por: Kubeček, Ondřej, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_l6kblt36teo9577a3q8uskfkd3