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Wound-Healing Peptides for Treatment of Chronic Diabetic Foot Ulcers and Other Infected Skin Injuries

As the incidence of diabetes continues to increase in the western world, the prevalence of chronic wounds related to this condition continues to be a major focus of wound care research. Additionally, over 50% of chronic wounds exhibit signs and symptoms that are consistent with localized bacterial b...

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Autores principales: Gomes, Ana, Teixeira, Cátia, Ferraz, Ricardo, Prudêncio, Cristina, Gomes, Paula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151519/
https://www.ncbi.nlm.nih.gov/pubmed/29057807
http://dx.doi.org/10.3390/molecules22101743
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author Gomes, Ana
Teixeira, Cátia
Ferraz, Ricardo
Prudêncio, Cristina
Gomes, Paula
author_facet Gomes, Ana
Teixeira, Cátia
Ferraz, Ricardo
Prudêncio, Cristina
Gomes, Paula
author_sort Gomes, Ana
collection PubMed
description As the incidence of diabetes continues to increase in the western world, the prevalence of chronic wounds related to this condition continues to be a major focus of wound care research. Additionally, over 50% of chronic wounds exhibit signs and symptoms that are consistent with localized bacterial biofilms underlying severe infections that contribute to tissue destruction, delayed wound-healing and other serious complications. Most current biomedical approaches for advanced wound care aim at providing antimicrobial protection to the open wound together with a matrix scaffold (often collagen-based) to boost reestablishment of the skin tissue. Therefore, the present review is focused on the efforts that have been made over the past years to find peptides possessing wound-healing properties, towards the development of new and effective wound care treatments for diabetic foot ulcers and other skin and soft tissue infections.
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spelling pubmed-61515192018-11-13 Wound-Healing Peptides for Treatment of Chronic Diabetic Foot Ulcers and Other Infected Skin Injuries Gomes, Ana Teixeira, Cátia Ferraz, Ricardo Prudêncio, Cristina Gomes, Paula Molecules Review As the incidence of diabetes continues to increase in the western world, the prevalence of chronic wounds related to this condition continues to be a major focus of wound care research. Additionally, over 50% of chronic wounds exhibit signs and symptoms that are consistent with localized bacterial biofilms underlying severe infections that contribute to tissue destruction, delayed wound-healing and other serious complications. Most current biomedical approaches for advanced wound care aim at providing antimicrobial protection to the open wound together with a matrix scaffold (often collagen-based) to boost reestablishment of the skin tissue. Therefore, the present review is focused on the efforts that have been made over the past years to find peptides possessing wound-healing properties, towards the development of new and effective wound care treatments for diabetic foot ulcers and other skin and soft tissue infections. MDPI 2017-10-18 /pmc/articles/PMC6151519/ /pubmed/29057807 http://dx.doi.org/10.3390/molecules22101743 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gomes, Ana
Teixeira, Cátia
Ferraz, Ricardo
Prudêncio, Cristina
Gomes, Paula
Wound-Healing Peptides for Treatment of Chronic Diabetic Foot Ulcers and Other Infected Skin Injuries
title Wound-Healing Peptides for Treatment of Chronic Diabetic Foot Ulcers and Other Infected Skin Injuries
title_full Wound-Healing Peptides for Treatment of Chronic Diabetic Foot Ulcers and Other Infected Skin Injuries
title_fullStr Wound-Healing Peptides for Treatment of Chronic Diabetic Foot Ulcers and Other Infected Skin Injuries
title_full_unstemmed Wound-Healing Peptides for Treatment of Chronic Diabetic Foot Ulcers and Other Infected Skin Injuries
title_short Wound-Healing Peptides for Treatment of Chronic Diabetic Foot Ulcers and Other Infected Skin Injuries
title_sort wound-healing peptides for treatment of chronic diabetic foot ulcers and other infected skin injuries
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151519/
https://www.ncbi.nlm.nih.gov/pubmed/29057807
http://dx.doi.org/10.3390/molecules22101743
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