NO-Donor Iron Nitrosyl Complex with N-Ethylthiourea Ligand Exhibits Selective Toxicity to Glioma A172 Cells

We studied effects of NO-donor iron nitrosyl complex with N-ethylthiourea ligand (ETM) on normal or tumor-derived cell lines. ETM was mildly toxic to most cell lines studied except the human glioma cell line A172 that proved to be highly sensitive to the complex and underwent cell death after ETM ex...

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Detalles Bibliográficos
Autores principales: Sanina, Nataliya, Shmatko, Natal’ya, Stupina, Tatiyana, Balakina, Anastasiya, Terent’ev, Alexei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151528/
https://www.ncbi.nlm.nih.gov/pubmed/28850075
http://dx.doi.org/10.3390/molecules22091426
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author Sanina, Nataliya
Shmatko, Natal’ya
Stupina, Tatiyana
Balakina, Anastasiya
Terent’ev, Alexei
author_facet Sanina, Nataliya
Shmatko, Natal’ya
Stupina, Tatiyana
Balakina, Anastasiya
Terent’ev, Alexei
author_sort Sanina, Nataliya
collection PubMed
description We studied effects of NO-donor iron nitrosyl complex with N-ethylthiourea ligand (ETM) on normal or tumor-derived cell lines. ETM was mildly toxic to most cell lines studied except the human glioma cell line A172 that proved to be highly sensitive to the complex and underwent cell death after ETM exposure. The high susceptibility of A172 cells to ETM was attributed to its NO-donor properties since no toxicity was detected for the N-ethylthiourea ligand.
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spelling pubmed-61515282018-11-13 NO-Donor Iron Nitrosyl Complex with N-Ethylthiourea Ligand Exhibits Selective Toxicity to Glioma A172 Cells Sanina, Nataliya Shmatko, Natal’ya Stupina, Tatiyana Balakina, Anastasiya Terent’ev, Alexei Molecules Article We studied effects of NO-donor iron nitrosyl complex with N-ethylthiourea ligand (ETM) on normal or tumor-derived cell lines. ETM was mildly toxic to most cell lines studied except the human glioma cell line A172 that proved to be highly sensitive to the complex and underwent cell death after ETM exposure. The high susceptibility of A172 cells to ETM was attributed to its NO-donor properties since no toxicity was detected for the N-ethylthiourea ligand. MDPI 2017-08-29 /pmc/articles/PMC6151528/ /pubmed/28850075 http://dx.doi.org/10.3390/molecules22091426 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sanina, Nataliya
Shmatko, Natal’ya
Stupina, Tatiyana
Balakina, Anastasiya
Terent’ev, Alexei
NO-Donor Iron Nitrosyl Complex with N-Ethylthiourea Ligand Exhibits Selective Toxicity to Glioma A172 Cells
title NO-Donor Iron Nitrosyl Complex with N-Ethylthiourea Ligand Exhibits Selective Toxicity to Glioma A172 Cells
title_full NO-Donor Iron Nitrosyl Complex with N-Ethylthiourea Ligand Exhibits Selective Toxicity to Glioma A172 Cells
title_fullStr NO-Donor Iron Nitrosyl Complex with N-Ethylthiourea Ligand Exhibits Selective Toxicity to Glioma A172 Cells
title_full_unstemmed NO-Donor Iron Nitrosyl Complex with N-Ethylthiourea Ligand Exhibits Selective Toxicity to Glioma A172 Cells
title_short NO-Donor Iron Nitrosyl Complex with N-Ethylthiourea Ligand Exhibits Selective Toxicity to Glioma A172 Cells
title_sort no-donor iron nitrosyl complex with n-ethylthiourea ligand exhibits selective toxicity to glioma a172 cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151528/
https://www.ncbi.nlm.nih.gov/pubmed/28850075
http://dx.doi.org/10.3390/molecules22091426
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