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Design, Synthesis and Biological Evaluation of N,N-Substituted Amine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors

N,N-Substituted amine derivatives were designed by utilizing a bioisosterism strategy. Consequently, twenty-two compounds were synthesized and evaluated for their inhibitory activity against CETP. Structure-activity relationship (SAR) studies indicate that hydrophilic groups at the 2-position of the...

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Detalles Bibliográficos
Autores principales:	Wang, Xinran, Hao, Lijuan, Xu, Xuanqi, Li, Wei, Liu, Chunchi, Zhao, Dongmei, Cheng, Maosheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151529/ https://www.ncbi.nlm.nih.gov/pubmed/28972557 http://dx.doi.org/10.3390/molecules22101658

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