Synthesis of 2,4-Diaminopyrimidine Core-Based Derivatives and Biological Evaluation of Their Anti-Tubercular Activities

Tuberculosis (TB) is a chronic, potentially fatal disease caused by Mycobacterium tuberculosis (Mtb). The dihyrofolate reductase in Mtb (mt-DHFR) is believed to be an important drug target in anti-TB drug development. This enzyme contains a glycerol (GOL) binding site, which is assumed to be a usefu...

Descripción completa

Detalles Bibliográficos
Autores principales: Ouyang, Yifan, Yang, Hao, Zhang, Peng, Wang, Yu, Kaur, Sargit, Zhu, Xuanli, Wang, Zhe, Sun, Yutong, Hong, Wei, Ngeow, Yun Fong, Wang, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151568/
https://www.ncbi.nlm.nih.gov/pubmed/28937657
http://dx.doi.org/10.3390/molecules22101592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151568/
https://www.ncbi.nlm.nih.gov/pubmed/28937657
http://dx.doi.org/10.3390/molecules22101592

Ejemplares similares