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Synthesis of 2,4-Diaminopyrimidine Core-Based Derivatives and Biological Evaluation of Their Anti-Tubercular Activities

Tuberculosis (TB) is a chronic, potentially fatal disease caused by Mycobacterium tuberculosis (Mtb). The dihyrofolate reductase in Mtb (mt-DHFR) is believed to be an important drug target in anti-TB drug development. This enzyme contains a glycerol (GOL) binding site, which is assumed to be a usefu...

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Detalles Bibliográficos
Autores principales:	Ouyang, Yifan, Yang, Hao, Zhang, Peng, Wang, Yu, Kaur, Sargit, Zhu, Xuanli, Wang, Zhe, Sun, Yutong, Hong, Wei, Ngeow, Yun Fong, Wang, Hao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151568/ https://www.ncbi.nlm.nih.gov/pubmed/28937657 http://dx.doi.org/10.3390/molecules22101592

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