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Influence of Jiegeng on Pharmacokinetic Properties of Flavonoids and Saponins in Gancao
Jiegeng Gancao decoction, which is composed of Jiegeng and Gancao at a weight ratio of 1:2, was widely used for treating pharyngalgia and cough for thousands of years. Our previous work indicated that Gancao could increase the systemic exposure of platycodin D and deapio-platycodin D, two main compo...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151572/ https://www.ncbi.nlm.nih.gov/pubmed/28934158 http://dx.doi.org/10.3390/molecules22101587 |
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author | Mao, Yancao Peng, Linxiu Kang, An Xie, Tong Xu, Jianya Shen, Cunsi Ji, Jianjian Di, Liuqing Wu, Hao Shan, Jinjun |
author_facet | Mao, Yancao Peng, Linxiu Kang, An Xie, Tong Xu, Jianya Shen, Cunsi Ji, Jianjian Di, Liuqing Wu, Hao Shan, Jinjun |
author_sort | Mao, Yancao |
collection | PubMed |
description | Jiegeng Gancao decoction, which is composed of Jiegeng and Gancao at a weight ratio of 1:2, was widely used for treating pharyngalgia and cough for thousands of years. Our previous work indicated that Gancao could increase the systemic exposure of platycodin D and deapio-platycodin D, two main components in Jiegeng. However, whether Jiegeng could alter the pharmacokinetics of the main compounds in Gancao is still unknown. Thus, the purpose of this study was to compare the oral pharmacokinetics of flavonoids and saponins from Gancao alone vs. after co-administration with Jiegeng. Furthermore, Caco-2 cell transport and fecal hydrolysis were investigated to explain the altered pharmacokinetic properties. Pharmacokinetics results suggested that the bioavailability of liquiritin, isoliquiritin, glycyrrhizin and its metabolite, glycyrrhetinic acid, could be improved while bioavailability of liquiritigenin and isoliquiritigenin deteriorated when co-administered with Jiegeng. The Caco-2 transport study showed no significant difference of the P(app) values of the main components in Jiegeng Gancao decoction when compared with those in Gancao decoction (p > 0.05). The in vitro metabolism study suggested that saponins and flavonoids glycosides in Gancao were influenced and the metabolic characteristics of most ingredients were consistent with pharmacokinetic results, such as liquiritin and glycyrrhetinic acid. The hydrolysis of liquiritigenin and glycyrrhizin observed with fecal lysate in vitro appeared consistent with the oral pharmacokinetics. Based on experiments, the pharmacokinetic profiles of six components in Gancao were influenced by Jiegeng. The metabolic process might partially contribute to the altered pharmacokinetic behavior. The metabolism of some components of Gancao appeared to be inhibited when coadministered with Jiegeng, possibly by the Jiegeng constituent platycodin. |
format | Online Article Text |
id | pubmed-6151572 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61515722018-11-13 Influence of Jiegeng on Pharmacokinetic Properties of Flavonoids and Saponins in Gancao Mao, Yancao Peng, Linxiu Kang, An Xie, Tong Xu, Jianya Shen, Cunsi Ji, Jianjian Di, Liuqing Wu, Hao Shan, Jinjun Molecules Article Jiegeng Gancao decoction, which is composed of Jiegeng and Gancao at a weight ratio of 1:2, was widely used for treating pharyngalgia and cough for thousands of years. Our previous work indicated that Gancao could increase the systemic exposure of platycodin D and deapio-platycodin D, two main components in Jiegeng. However, whether Jiegeng could alter the pharmacokinetics of the main compounds in Gancao is still unknown. Thus, the purpose of this study was to compare the oral pharmacokinetics of flavonoids and saponins from Gancao alone vs. after co-administration with Jiegeng. Furthermore, Caco-2 cell transport and fecal hydrolysis were investigated to explain the altered pharmacokinetic properties. Pharmacokinetics results suggested that the bioavailability of liquiritin, isoliquiritin, glycyrrhizin and its metabolite, glycyrrhetinic acid, could be improved while bioavailability of liquiritigenin and isoliquiritigenin deteriorated when co-administered with Jiegeng. The Caco-2 transport study showed no significant difference of the P(app) values of the main components in Jiegeng Gancao decoction when compared with those in Gancao decoction (p > 0.05). The in vitro metabolism study suggested that saponins and flavonoids glycosides in Gancao were influenced and the metabolic characteristics of most ingredients were consistent with pharmacokinetic results, such as liquiritin and glycyrrhetinic acid. The hydrolysis of liquiritigenin and glycyrrhizin observed with fecal lysate in vitro appeared consistent with the oral pharmacokinetics. Based on experiments, the pharmacokinetic profiles of six components in Gancao were influenced by Jiegeng. The metabolic process might partially contribute to the altered pharmacokinetic behavior. The metabolism of some components of Gancao appeared to be inhibited when coadministered with Jiegeng, possibly by the Jiegeng constituent platycodin. MDPI 2017-09-21 /pmc/articles/PMC6151572/ /pubmed/28934158 http://dx.doi.org/10.3390/molecules22101587 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mao, Yancao Peng, Linxiu Kang, An Xie, Tong Xu, Jianya Shen, Cunsi Ji, Jianjian Di, Liuqing Wu, Hao Shan, Jinjun Influence of Jiegeng on Pharmacokinetic Properties of Flavonoids and Saponins in Gancao |
title | Influence of Jiegeng on Pharmacokinetic Properties of Flavonoids and Saponins in Gancao |
title_full | Influence of Jiegeng on Pharmacokinetic Properties of Flavonoids and Saponins in Gancao |
title_fullStr | Influence of Jiegeng on Pharmacokinetic Properties of Flavonoids and Saponins in Gancao |
title_full_unstemmed | Influence of Jiegeng on Pharmacokinetic Properties of Flavonoids and Saponins in Gancao |
title_short | Influence of Jiegeng on Pharmacokinetic Properties of Flavonoids and Saponins in Gancao |
title_sort | influence of jiegeng on pharmacokinetic properties of flavonoids and saponins in gancao |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151572/ https://www.ncbi.nlm.nih.gov/pubmed/28934158 http://dx.doi.org/10.3390/molecules22101587 |
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