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Cholesterol Flip-Flop Impacts Domain Registration in Plasma Membrane Models
[Image: see text] The plasma membrane is a highly complex multicomponent system that is central to the functioning of cells. Cholesterol, a key lipid component of the plasma membrane, promotes the formation of nanodomains. These nanodomains are often correlated across the two membrane leaflets, but...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151656/ https://www.ncbi.nlm.nih.gov/pubmed/30192549 http://dx.doi.org/10.1021/acs.jpclett.8b01877 |
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author | Thallmair, Sebastian Ingólfsson, Helgi I. Marrink, Siewert J. |
author_facet | Thallmair, Sebastian Ingólfsson, Helgi I. Marrink, Siewert J. |
author_sort | Thallmair, Sebastian |
collection | PubMed |
description | [Image: see text] The plasma membrane is a highly complex multicomponent system that is central to the functioning of cells. Cholesterol, a key lipid component of the plasma membrane, promotes the formation of nanodomains. These nanodomains are often correlated across the two membrane leaflets, but the underlying physical mechanism remains unclear. Using coarse-grained molecular dynamics simulations, we investigate the influence of cholesterol flip-flop on membrane properties, in particular, the interleaflet coupling of cholesterol-enriched domains. We show that the cholesterol density correlation between the leaflets of an average mammalian plasma membrane is significantly reduced by suppressing interleaflet cholesterol population. Our results suggest an amplifying role of cholesterol in signal transduction across the leaflets. |
format | Online Article Text |
id | pubmed-6151656 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | American Chemical
Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-61516562018-09-25 Cholesterol Flip-Flop Impacts Domain Registration in Plasma Membrane Models Thallmair, Sebastian Ingólfsson, Helgi I. Marrink, Siewert J. J Phys Chem Lett [Image: see text] The plasma membrane is a highly complex multicomponent system that is central to the functioning of cells. Cholesterol, a key lipid component of the plasma membrane, promotes the formation of nanodomains. These nanodomains are often correlated across the two membrane leaflets, but the underlying physical mechanism remains unclear. Using coarse-grained molecular dynamics simulations, we investigate the influence of cholesterol flip-flop on membrane properties, in particular, the interleaflet coupling of cholesterol-enriched domains. We show that the cholesterol density correlation between the leaflets of an average mammalian plasma membrane is significantly reduced by suppressing interleaflet cholesterol population. Our results suggest an amplifying role of cholesterol in signal transduction across the leaflets. American Chemical Society 2018-09-07 2018-09-20 /pmc/articles/PMC6151656/ /pubmed/30192549 http://dx.doi.org/10.1021/acs.jpclett.8b01877 Text en Copyright © 2018 American Chemical Society This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License (http://pubs.acs.org/page/policy/authorchoice_ccbyncnd_termsofuse.html) , which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes. |
spellingShingle | Thallmair, Sebastian Ingólfsson, Helgi I. Marrink, Siewert J. Cholesterol Flip-Flop Impacts Domain Registration in Plasma Membrane Models |
title | Cholesterol Flip-Flop Impacts Domain Registration
in Plasma Membrane Models |
title_full | Cholesterol Flip-Flop Impacts Domain Registration
in Plasma Membrane Models |
title_fullStr | Cholesterol Flip-Flop Impacts Domain Registration
in Plasma Membrane Models |
title_full_unstemmed | Cholesterol Flip-Flop Impacts Domain Registration
in Plasma Membrane Models |
title_short | Cholesterol Flip-Flop Impacts Domain Registration
in Plasma Membrane Models |
title_sort | cholesterol flip-flop impacts domain registration
in plasma membrane models |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151656/ https://www.ncbi.nlm.nih.gov/pubmed/30192549 http://dx.doi.org/10.1021/acs.jpclett.8b01877 |
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