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Cyclodipeptides: An Overview of Their Biosynthesis and Biological Activity

Cyclodipeptides (CDP) represent a diverse family of small, highly stable, cyclic peptides that are produced as secondary functional metabolites or side products of protein metabolism by bacteria, fungi, and animals. They are widespread in nature, and exhibit a broad variety of biological and pharmac...

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Autores principales: Mishra, Awdhesh Kumar, Choi, Jaehyuk, Choi, Seong-Jin, Baek, Kwang-Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151668/
https://www.ncbi.nlm.nih.gov/pubmed/29065531
http://dx.doi.org/10.3390/molecules22101796
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author Mishra, Awdhesh Kumar
Choi, Jaehyuk
Choi, Seong-Jin
Baek, Kwang-Hyun
author_facet Mishra, Awdhesh Kumar
Choi, Jaehyuk
Choi, Seong-Jin
Baek, Kwang-Hyun
author_sort Mishra, Awdhesh Kumar
collection PubMed
description Cyclodipeptides (CDP) represent a diverse family of small, highly stable, cyclic peptides that are produced as secondary functional metabolites or side products of protein metabolism by bacteria, fungi, and animals. They are widespread in nature, and exhibit a broad variety of biological and pharmacological activities. CDP synthases (CDPSs) and non-ribosomal peptide synthetases (NRPSs) catalyze the biosynthesis of the CDP core structure, which is further modified by tailoring enzymes often associated with CDP biosynthetic gene clusters. In this review, we provide a comprehensive summary of CDP biosynthetic pathways and modifying enzymes. We also discuss the biological properties of some known CDPs and their possible applications in metabolic engineering.
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spelling pubmed-61516682018-11-13 Cyclodipeptides: An Overview of Their Biosynthesis and Biological Activity Mishra, Awdhesh Kumar Choi, Jaehyuk Choi, Seong-Jin Baek, Kwang-Hyun Molecules Review Cyclodipeptides (CDP) represent a diverse family of small, highly stable, cyclic peptides that are produced as secondary functional metabolites or side products of protein metabolism by bacteria, fungi, and animals. They are widespread in nature, and exhibit a broad variety of biological and pharmacological activities. CDP synthases (CDPSs) and non-ribosomal peptide synthetases (NRPSs) catalyze the biosynthesis of the CDP core structure, which is further modified by tailoring enzymes often associated with CDP biosynthetic gene clusters. In this review, we provide a comprehensive summary of CDP biosynthetic pathways and modifying enzymes. We also discuss the biological properties of some known CDPs and their possible applications in metabolic engineering. MDPI 2017-10-23 /pmc/articles/PMC6151668/ /pubmed/29065531 http://dx.doi.org/10.3390/molecules22101796 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mishra, Awdhesh Kumar
Choi, Jaehyuk
Choi, Seong-Jin
Baek, Kwang-Hyun
Cyclodipeptides: An Overview of Their Biosynthesis and Biological Activity
title Cyclodipeptides: An Overview of Their Biosynthesis and Biological Activity
title_full Cyclodipeptides: An Overview of Their Biosynthesis and Biological Activity
title_fullStr Cyclodipeptides: An Overview of Their Biosynthesis and Biological Activity
title_full_unstemmed Cyclodipeptides: An Overview of Their Biosynthesis and Biological Activity
title_short Cyclodipeptides: An Overview of Their Biosynthesis and Biological Activity
title_sort cyclodipeptides: an overview of their biosynthesis and biological activity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151668/
https://www.ncbi.nlm.nih.gov/pubmed/29065531
http://dx.doi.org/10.3390/molecules22101796
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