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Chronic, Recreational Chloroform-Induced Liver Injury
Historically used as an anesthetic, chloroform is a halogenated hydrocarbon that is associated with central nervous system depression, arrhythmias, and hepatotoxicity. It is no longer used clinically, but accidental and intentional poisonings still occur. We report a case of chronic chloroform abuse...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151676/ https://www.ncbi.nlm.nih.gov/pubmed/30275992 http://dx.doi.org/10.1155/2018/1619546 |
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author | Minor, Emily A. Newman, Mackenzie S. Kupec, Justin T. |
author_facet | Minor, Emily A. Newman, Mackenzie S. Kupec, Justin T. |
author_sort | Minor, Emily A. |
collection | PubMed |
description | Historically used as an anesthetic, chloroform is a halogenated hydrocarbon that is associated with central nervous system depression, arrhythmias, and hepatotoxicity. It is no longer used clinically, but accidental and intentional poisonings still occur. We report a case of chronic chloroform abuse leading to severe hepatotoxicity in a 26-year-old male graduate student. The patient presented to the emergency department with a three-day history of abdominal pain, dehydration, and scleral icterus. He drank several beers the night before the onset of symptoms, but denied taking acetaminophen, ibuprofen, or other drugs. An extensive work-up revealed an aspartate aminotransferase (AST) of 13,527 U/L and alanine aminotransferase (ALT) of 8,745 U/L, but the cause of his liver injury could not be determined. It was not until many months later that the patient admitted to inhaling chloroform in the weeks leading up to his illness. |
format | Online Article Text |
id | pubmed-6151676 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-61516762018-10-01 Chronic, Recreational Chloroform-Induced Liver Injury Minor, Emily A. Newman, Mackenzie S. Kupec, Justin T. Case Reports Hepatol Case Report Historically used as an anesthetic, chloroform is a halogenated hydrocarbon that is associated with central nervous system depression, arrhythmias, and hepatotoxicity. It is no longer used clinically, but accidental and intentional poisonings still occur. We report a case of chronic chloroform abuse leading to severe hepatotoxicity in a 26-year-old male graduate student. The patient presented to the emergency department with a three-day history of abdominal pain, dehydration, and scleral icterus. He drank several beers the night before the onset of symptoms, but denied taking acetaminophen, ibuprofen, or other drugs. An extensive work-up revealed an aspartate aminotransferase (AST) of 13,527 U/L and alanine aminotransferase (ALT) of 8,745 U/L, but the cause of his liver injury could not be determined. It was not until many months later that the patient admitted to inhaling chloroform in the weeks leading up to his illness. Hindawi 2018-09-10 /pmc/articles/PMC6151676/ /pubmed/30275992 http://dx.doi.org/10.1155/2018/1619546 Text en Copyright © 2018 Emily A. Minor et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Minor, Emily A. Newman, Mackenzie S. Kupec, Justin T. Chronic, Recreational Chloroform-Induced Liver Injury |
title | Chronic, Recreational Chloroform-Induced Liver Injury |
title_full | Chronic, Recreational Chloroform-Induced Liver Injury |
title_fullStr | Chronic, Recreational Chloroform-Induced Liver Injury |
title_full_unstemmed | Chronic, Recreational Chloroform-Induced Liver Injury |
title_short | Chronic, Recreational Chloroform-Induced Liver Injury |
title_sort | chronic, recreational chloroform-induced liver injury |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151676/ https://www.ncbi.nlm.nih.gov/pubmed/30275992 http://dx.doi.org/10.1155/2018/1619546 |
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