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Synthesis and Antitumor Activity of Triazole-Containing Sorafenib Analogs

Using a highly effective binuclear Cu complex as the catalyst, the 1,3-dipolar cycloaddition reactions between 16 alkynes and two azides were successfully performed and resulted in the production of 25 new triazole-containing sorafenib analogs. Several compounds were evaluated as potent antitumor ag...

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Detalles Bibliográficos
Autores principales:	Ye, Wenjing, Yao, Qi, Yu, Simiao, Gong, Ping, Qin, Mingze
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151694/ https://www.ncbi.nlm.nih.gov/pubmed/29064424 http://dx.doi.org/10.3390/molecules22101759

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