Nucleophilicities of Lewis Bases B and Electrophilicities of Lewis Acids A Determined from the Dissociation Energies of Complexes B⋯A Involving Hydrogen Bonds, Tetrel Bonds, Pnictogen Bonds, Chalcogen Bonds and Halogen Bonds

It is shown that the dissociation energy [Formula: see text] for the process B⋯A = B + A for 250 complexes B⋯A composed of 11 Lewis bases B (N(2), CO, HC≡CH, CH(2)=CH(2), C(3)H(6), PH(3), H(2)S, HCN, H(2)O, H(2)CO and NH(3)) and 23 Lewis acids (HF, HCl, HBr, HC≡CH, HCN, H(2)O, F(2), Cl(2), Br(2), ClF, BrCl, H(3)SiF, H(3)GeF, F(2)CO, CO(2), N(2)O, NO(2)F, PH(2)F, AsH(2)F, SO(2), SeO(2), SF(2), and SeF(2)) can be represented to good approximation by means of the equation [Formula: see text] , in which [Formula: see text] is a numerical nucleophilicity assigned to B, [Formula: see text] is a numerical electrophilicity assigned to A, and [Formula: see text] is a constant, conveniently chosen to have the value 1.00 kJ mol(−1) here. The 250 complexes were chosen to cover a wide range of non-covalent interaction types, namely: (1) the hydrogen bond; (2) the halogen bond; (3) the tetrel bond; (4) the pnictogen bond; and (5) the chalcogen bond. Since there is no evidence that one group of non-covalent interaction was fitted any better than the others, it appears the equation is equally valid for all the interactions considered and that the values of [Formula: see text] and [Formula: see text] so determined define properties of the individual molecules. The values of [Formula: see text] and [Formula: see text] can be used to predict the dissociation energies of a wide range of binary complexes B⋯A with reasonable accuracy.