Cargando…

Construction of a Bivalent Thrombin Binding Aptamer and Its Antidote with Improved Properties

Aptamers are short synthetic DNA or RNA oligonucleotides that adopt secondary and tertiary conformations based on Watson–Crick base-pairing interactions and can be used to target a range of different molecules. Two aptamers, HD1 and HD22, that bind to exosites I and II of the human thrombin molecule...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hughes, Quintin W., Le, Bao T., Gilmore, Grace, Baker, Ross I., Veedu, Rakesh N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151750/ https://www.ncbi.nlm.nih.gov/pubmed/29048375 http://dx.doi.org/10.3390/molecules22101770

Ejemplares similares

Design strategy of antidote sequence for bivalent aptamer: Rapid neutralization of high‐anticoagulant thrombin‐binding bivalent DNA aptamer‐linked M08 with HD22
por: Yoshitomi, Toru, et al.
Publicado: (2021)

Development of an Efficient G‐Quadruplex‐Stabilised Thrombin‐Binding Aptamer Containing a Three‐Carbon Spacer Molecule
por: Aaldering, Lukas J., et al.
Publicado: (2017)

New High-Affinity Thrombin Aptamers for Advancing Coagulation Therapy: Balancing Thrombin Inhibition for Clot Prevention and Effective Bleeding Management with Antidote
por: Ayass, Mohamad Ammar, et al.
Publicado: (2023)

Unlocked nucleic acid modified primer-based enzymatic polymerization assay: towards allele-specific genotype detection of human platelet antigens
por: Le, Bao T., et al.
Publicado: (2018)

Rapid Complexation of Aptamers by Their Specific Antidotes
por: Stoll, Heidi, et al.
Publicado: (2017)

Alpha-Deoxyguanosine to Reshape the Alpha-Thrombin Binding Aptamer
por: Kolganova, Natalia A., et al.
Publicado: (2023)

Selection of an Aptamer Antidote to the Anticoagulant Drug Bivalirudin
por: Martin, Jennifer A., et al.
Publicado: (2013)

Mathematical modeling to understand the role of bivalent thrombin-fibrin binding during polymerization
por: Kelley, Michael A., et al.
Publicado: (2022)

Thermodynamic, Anticoagulant, and Antiproliferative Properties of Thrombin Binding Aptamer Containing Novel UNA Derivative
por: Kotkowiak, Weronika, et al.
Publicado: (2017)

Structural and Binding Effects of Chemical Modifications on Thrombin Binding Aptamer (TBA)
por: Valsangkar, Vibhav, et al.
Publicado: (2021)

High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity
por: Russo Krauss, Irene, et al.
Publicado: (2012)

Thrombin-Binding Aptamer Quadruplex Formation: AFM and Voltammetric Characterization
por: Diculescu, Victor Constantin, et al.
Publicado: (2010)

Comparison of the ‘Chemical’ and ‘Structural’ Approaches to the Optimization of the Thrombin-Binding Aptamer
por: Tatarinova, Olga, et al.
Publicado: (2014)

Structural properties and anticoagulant/cytotoxic activities of heterochiral enantiomeric thrombin binding aptamer (TBA) derivatives
por: Virgilio, Antonella, et al.
Publicado: (2020)

Thrombin-Binding Aptamer with Inversion of Polarity Sites (IPS): Effect on DNAzyme Activity and Anticoagulant Properties
por: Kosman, Joanna, et al.
Publicado: (2021)

The Organophosphate Paraoxon and Its Antidote Obidoxime Inhibit Thrombin Activity and Affect Coagulation In Vitro
por: Golderman, Valery, et al.
Publicado: (2016)

Electrical Stimulus Controlled Binding/Unbinding of Human Thrombin-Aptamer Complex
por: Gosai, Agnivo, et al.
Publicado: (2016)

Thrombin binding aptamer G-quadruplex stabilized by pyrene-modified nucleotides
por: Kovačič, Matic, et al.
Publicado: (2020)

Experimental and mathematical evidence that thrombin-binding aptamers form a 1 aptamer:2 protein complex
por: Mears, Kepler S, et al.
Publicado: (2018)

Recognition Interface of the Thrombin Binding Aptamer Requires Antiparallel Topology of the Quadruplex Core
por: Svetlova, Julia, et al.
Publicado: (2021)

Properties and Potential Antiproliferative Activity of Thrombin-Binding Aptamer (TBA) Derivatives with One or Two Additional G-Tetrads
por: Benigno, Daniela, et al.
Publicado: (2022)

Aptamer-engineered (nano)materials for theranostic applications
por: Rabiee, Navid, et al.
Publicado: (2023)

Thrombin–aptamer recognition: a revealed ambiguity
por: Russo Krauss, Irene, et al.
Publicado: (2011)

Aptamer Based Microsphere Biosensor for Thrombin Detection
por: Zhu, Hongying, et al.
Publicado: (2006)

Improved thrombin binding aptamer by incorporation of a single unlocked nucleic acid monomer
por: Pasternak, Anna, et al.
Publicado: (2011)

In silico direct folding of thrombin-binding aptamer G-quadruplex at all-atom level
por: Yang, Changwon, et al.
Publicado: (2017)

Rapidly Neutralizable and Highly Anticoagulant Thrombin-Binding DNA Aptamer Discovered by MACE SELEX
por: Wakui, Koji, et al.
Publicado: (2019)

A Comprehensive Analysis of the Thrombin Binding Aptamer Containing Functionalized Pyrrolo-2’-deoxycytidines
por: Kotkowiak, Weronika, et al.
Publicado: (2021)

Improving the Biological Properties of Thrombin-Binding Aptamer by Incorporation of 8-Bromo-2′-Deoxyguanosine and 2′-Substituted RNA Analogues
por: Virgilio, Antonella, et al.
Publicado: (2023)

Rapid molecular imaging of active thrombi in vivo using aptamer-antidote probes
por: Gray, Bethany Powell, et al.
Publicado: (2023)

Protocol for purification of cells in their native state using reversible aptamer-antidote pairs
por: Requena, Martin D., et al.
Publicado: (2023)

Radiolabeling of Nucleic Acid Aptamers for Highly Sensitive Disease-Specific Molecular Imaging
por: Hassanzadeh, Leila, et al.
Publicado: (2018)

Construction of Electrochemical Aptamer Sensor Based on Pt-Coordinated Titanium-Based Porphyrin MOF for Thrombin Detection
por: Jiang, Jiazi, et al.
Publicado: (2022)

Development and Optimization of a Thrombin Sandwich Aptamer Microarray
por: Meneghello, Anna, et al.
Publicado: (2012)

Different duplex/quadruplex junctions determine the properties of anti-thrombin aptamers with mixed folding
por: Russo Krauss, Irene, et al.
Publicado: (2016)

Different duplex/quadruplex junctions determine the properties of anti-thrombin aptamers with mixed folding
por: Russo Krauss, Irene, et al.
Publicado: (2016)

Direct Detection of Thrombin Binding to 8-Bromodeoxyguanosine-Modified Aptamer: Effects of Modification on Affinity and Kinetics
por: Goji, Shou, et al.
Publicado: (2011)

Unfolding mechanism of thrombin-binding aptamer revealed by molecular dynamics simulation and Markov State Model
por: Zeng, Xiaojun, et al.
Publicado: (2016)

Exosite Binding in Thrombin: A Global Structural/Dynamic Overview of Complexes with Aptamers and Other Ligands
por: Troisi, Romualdo, et al.
Publicado: (2021)

A terminal functionalization strategy reveals unusual binding abilities of anti-thrombin anticoagulant aptamers
por: Troisi, Romualdo, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_0337c9ku8bscutsaaqdrqrjae1