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Effects of Sleep Quality on Melatonin Levels and Inflammatory Response after Major Abdominal Surgery in an Intensive Care Unit

Disruption of nocturnal sleep in an intensive care unit may remarkably affect production of melatonin, which is also known to have anti-inflammatory properties. In the present study, we aimed to investigate the effect of sleep quality on melatonin levels and inflammation after surgery. Thus, we comp...

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Autores principales: Yaşar, Necdet Fatih, Badak, Bartu, Canik, Ağgül, Baş, Sema Şanal, Uslu, Sema, Öner, Setenay, Ateş, Ersin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151787/
https://www.ncbi.nlm.nih.gov/pubmed/28895895
http://dx.doi.org/10.3390/molecules22091537
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author Yaşar, Necdet Fatih
Badak, Bartu
Canik, Ağgül
Baş, Sema Şanal
Uslu, Sema
Öner, Setenay
Ateş, Ersin
author_facet Yaşar, Necdet Fatih
Badak, Bartu
Canik, Ağgül
Baş, Sema Şanal
Uslu, Sema
Öner, Setenay
Ateş, Ersin
author_sort Yaşar, Necdet Fatih
collection PubMed
description Disruption of nocturnal sleep in an intensive care unit may remarkably affect production of melatonin, which is also known to have anti-inflammatory properties. In the present study, we aimed to investigate the effect of sleep quality on melatonin levels and inflammation after surgery. Thus, we compared the patients, who were screened in the side-rooms where the lights were dimmed and noise levels were reduced, with the patients who received usual care. Preoperative and postoperative urine 6-sulphatoxymelatonin, serum interleukin-1 (IL-1), interleukin-6 (IL-6), and c-reactive protein (CRP) levels were measured and data on sleep quality was collected using the Richards–Campbell Sleep Questionnaire. Postoperative CRP and IL-6 levels were greater in the control group than in the experimental group, whereas postoperative 24 h melatonin levels were greater than preoperative levels and the difference was steeper in the experimental group in concordance with sleep quality scores. Thus, the regulation of light and noise in ICUs may help the recovery after major surgeries in patients, potentially by increasing melatonin production, which has anti-inflammatory properties.
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spelling pubmed-61517872018-11-13 Effects of Sleep Quality on Melatonin Levels and Inflammatory Response after Major Abdominal Surgery in an Intensive Care Unit Yaşar, Necdet Fatih Badak, Bartu Canik, Ağgül Baş, Sema Şanal Uslu, Sema Öner, Setenay Ateş, Ersin Molecules Article Disruption of nocturnal sleep in an intensive care unit may remarkably affect production of melatonin, which is also known to have anti-inflammatory properties. In the present study, we aimed to investigate the effect of sleep quality on melatonin levels and inflammation after surgery. Thus, we compared the patients, who were screened in the side-rooms where the lights were dimmed and noise levels were reduced, with the patients who received usual care. Preoperative and postoperative urine 6-sulphatoxymelatonin, serum interleukin-1 (IL-1), interleukin-6 (IL-6), and c-reactive protein (CRP) levels were measured and data on sleep quality was collected using the Richards–Campbell Sleep Questionnaire. Postoperative CRP and IL-6 levels were greater in the control group than in the experimental group, whereas postoperative 24 h melatonin levels were greater than preoperative levels and the difference was steeper in the experimental group in concordance with sleep quality scores. Thus, the regulation of light and noise in ICUs may help the recovery after major surgeries in patients, potentially by increasing melatonin production, which has anti-inflammatory properties. MDPI 2017-09-12 /pmc/articles/PMC6151787/ /pubmed/28895895 http://dx.doi.org/10.3390/molecules22091537 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yaşar, Necdet Fatih
Badak, Bartu
Canik, Ağgül
Baş, Sema Şanal
Uslu, Sema
Öner, Setenay
Ateş, Ersin
Effects of Sleep Quality on Melatonin Levels and Inflammatory Response after Major Abdominal Surgery in an Intensive Care Unit
title Effects of Sleep Quality on Melatonin Levels and Inflammatory Response after Major Abdominal Surgery in an Intensive Care Unit
title_full Effects of Sleep Quality on Melatonin Levels and Inflammatory Response after Major Abdominal Surgery in an Intensive Care Unit
title_fullStr Effects of Sleep Quality on Melatonin Levels and Inflammatory Response after Major Abdominal Surgery in an Intensive Care Unit
title_full_unstemmed Effects of Sleep Quality on Melatonin Levels and Inflammatory Response after Major Abdominal Surgery in an Intensive Care Unit
title_short Effects of Sleep Quality on Melatonin Levels and Inflammatory Response after Major Abdominal Surgery in an Intensive Care Unit
title_sort effects of sleep quality on melatonin levels and inflammatory response after major abdominal surgery in an intensive care unit
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151787/
https://www.ncbi.nlm.nih.gov/pubmed/28895895
http://dx.doi.org/10.3390/molecules22091537
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