A New Series of Cytotoxic Pyrazoline Derivatives as Potential Anticancer Agents that Induce Cell Cycle Arrest and Apoptosis

A new series of pyrazoline derivatives 1b–12b was designed, synthesized and evaluated for antiproliferative activity against three cancer cell lines (HepG-2, Hela and A549). Additionally, NIH/3T3 cell cytotoxicity were tested and the structure activity relationships (SARs) were also determined. Amon...

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Detalles Bibliográficos
Autores principales: Wang, Hong, Zheng, Jinhong, Xu, Weijie, Chen, Cheng, Wei, Duncan, Ni, Wenxiu, Pan, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151802/
https://www.ncbi.nlm.nih.gov/pubmed/28961210
http://dx.doi.org/10.3390/molecules22101635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151802/
https://www.ncbi.nlm.nih.gov/pubmed/28961210
http://dx.doi.org/10.3390/molecules22101635

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