Why is Aged Acetylcholinesterase So Difficult to Reactivate?

Organophosphorus agents are potent inhibitors of acetylcholinesterase. Inhibition involves successive chemical events. The first is phosphylation of the active site serine to produce a neutral adduct, which is a close structural analog of the acylation transition state. This adduct is unreactive tow...

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Detalles Bibliográficos
Autores principales: Quinn, Daniel M., Topczewski, Joseph, Yasapala, Nilanthi, Lodge, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151809/
https://www.ncbi.nlm.nih.gov/pubmed/28869561
http://dx.doi.org/10.3390/molecules22091464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151809/
https://www.ncbi.nlm.nih.gov/pubmed/28869561
http://dx.doi.org/10.3390/molecules22091464

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