Aspalathin Reverts Doxorubicin-Induced Cardiotoxicity through Increased Autophagy and Decreased Expression of p53/mTOR/p62 Signaling

Doxorubicin (Dox) is an effective chemotherapeutic agent used in the treatment of various cancers. Its clinical use is often limited due to its potentially fatal cardiotoxic side effect. Increasing evidence indicates that tumour protein p53 (p53), adenosine monophosphate-activated protein kinase (AM...

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Detalles Bibliográficos
Autores principales: Johnson, Rabia, Shabalala, Samukelisiwe, Louw, Johan, Kappo, Abidemi Paul, Muller, Christo John Frederick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151817/
https://www.ncbi.nlm.nih.gov/pubmed/28937626
http://dx.doi.org/10.3390/molecules22101589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151817/
https://www.ncbi.nlm.nih.gov/pubmed/28937626
http://dx.doi.org/10.3390/molecules22101589

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