Cargando…

Synthesis and biological evaluation of pyrrolidine-based T-type calcium channel inhibitors for the treatment of neuropathic pain

The treatment of neuropathic pain is one of the urgent unmet medical needs and T-type calcium channels are promising therapeutic targets for neuropathic pain. Several potent T-type channel inhibitors showed promising in vivo efficacy in neuropathic pain animal models and are being investigated in cl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Hak Kyun, Son, Woo Seung, Lim, Keon Seung, Kim, Gun Hee, Lim, Eun Jeong, Gadhe, Changdev G., Lee, Jae Yeol, Jeong, Kyu-Sung, Lim, Sang Min, Pae, Ae Nim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151954/ https://www.ncbi.nlm.nih.gov/pubmed/30231778 http://dx.doi.org/10.1080/14756366.2018.1513926

Ejemplares similares

Investigation of Molecular Details of Keap1-Nrf2 Inhibitors Using Molecular Dynamics and Umbrella Sampling Techniques
por: Londhe, Ashwini Machhindra, et al.
Publicado: (2019)

Glutamate Permeability of Chicken Best1
por: Lee, Jung Moo, et al.
Publicado: (2022)

Development of an Aryloxazole Derivative as a Brain-Permeable Anti-Glioblastoma Agent
por: Shin, Seulgi, et al.
Publicado: (2019)

3-Carene, a Phytoncide from Pine Tree Has a Sleep-enhancing Effect by Targeting the GABA(A)-benzodiazepine Receptors
por: Woo, Junsung, et al.
Publicado: (2019)

Development of Oxadiazole-Based ODZ10117 as a Small-Molecule Inhibitor of STAT3 for Targeted Cancer Therapy
por: Kim, Byung-Hak, et al.
Publicado: (2019)

Structural Insights from Binding Poses of CCR2 and CCR5 with Clinically Important Antagonists: A Combined In Silico Study
por: Kothandan, Gugan, et al.
Publicado: (2012)

In Silico Quantitative Structure-Activity Relationship Studies on P-gp Modulators of Tetrahydroisoquinoline-Ethyl-Phenylamine Series
por: Gadhe, Changdev G, et al.
Publicado: (2011)

Mitochondrial dysfunction and Alzheimer’s disease: prospects for therapeutic intervention
por: Lim, Ji Woong, et al.
Publicado: (2020)

A Protoberberine Derivative HWY336 Selectively Inhibits MKK4 and MKK7 in Mammalian Cells: The Importance of Activation Loop on Selectivity
por: Kim, Namil, et al.
Publicado: (2014)

Pharmacophore-Based Virtual Screening of Novel Competitive Inhibitors of the Neurodegenerative Disease Target Kynurenine-3-Monooxygenase
por: Gotina, Lizaveta, et al.
Publicado: (2021)

9-[(E)-2-(2-Methoxyphenyl)ethenyl]-3,4,5,6,7,9-hexahydro-2H-xanthene-1,8-dione
por: Cha, Joo Hwan, et al.
Publicado: (2012)

(E)-9-(4-Chlorostyryl)-3,4,5,6,7,9-hexahydro-2H-xanthene-1,8-dione
por: Lee, Jae Kyun, et al.
Publicado: (2012)

T-type calcium channel modulation by hydrogen sulfide in neuropathic pain conditions
por: Rangel-Galván, Maricruz, et al.
Publicado: (2023)

Direct interaction with 14–3-3γ promotes surface expression of Best1 channel in astrocyte
por: Oh, Soo-Jin, et al.
Publicado: (2017)

(E)-N-[(E)-3-(4-Nitrophenyl)allylidene]naphthalen-1-amine
por: Nam, Kee Dal, et al.
Publicado: (2013)

Guided bone regeneration using demineralized allogenic bone matrix with calcium sulfate: case series
por: Kim, Young-Kyun, et al.
Publicado: (2013)

Propofol and Aminophylline Antagonize Each Other During the Mobilization of Intracellular Calcium in Human Umbilical Vein Endothelial Cells
por: Son, Hee-Jeong, et al.
Publicado: (2010)

Targeted ubiquitination of sensory neuron calcium channels reduces the development of neuropathic pain
por: Sun, Linlin, et al.
Publicado: (2022)

Myometrial relaxation of mice via expression of two pore domain acid sensitive K(+) (TASK-2) channels
por: Kyeong, Kyu-Sang, et al.
Publicado: (2016)

Reversal of Neuropathic Pain in Diabetes by Targeting Glycosylation of Ca(v)3.2 T-Type Calcium Channels
por: Orestes, Peihan, et al.
Publicado: (2013)

Food-Derived Natural Compounds for Pain Relief in Neuropathic Pain
por: Lim, Eun Yeong, et al.
Publicado: (2016)

A case report of traditional Korean medicine treatments on uterine myoma with thyroid cancer
por: Lim, Chae-Hak, et al.
Publicado: (2018)

Evaluation of the relationship between non-caries cervical lesions and the tooth and periodontal tissue: An ex-vivo study using micro-computed tomography
por: Lim, Go-Eun, et al.
Publicado: (2020)

Bee Venom and Its Peptide Component Melittin Suppress Growth and Migration of Melanoma Cells via Inhibition of PI3K/AKT/mTOR and MAPK Pathways
por: Lim, Haet Nim, et al.
Publicado: (2019)

Protective Effects of Gabapentin on Allodynia and α(2)δ(1)-Subunit of Voltage-dependent Calcium Channel in Spinal Nerve-Ligated Rats
por: Hahm, Tae Soo, et al.
Publicado: (2009)

Pyrrolidine Dithiocarbamate Suppresses Cutibacterium acnes-Induced Skin Inflammation
por: Shin, Jin Hak, et al.
Publicado: (2023)

Comparative phenolic compound profiles and antioxidative activity of the fruit, leaves, and roots of Korean ginseng (Panax ginseng Meyer) according to cultivation years
por: Chung, Ill-Min, et al.
Publicado: (2016)

Mechanisms of the gabapentinoids and α (2) δ‐1 calcium channel subunit in neuropathic pain
por: Patel, Ryan, et al.
Publicado: (2016)

Alleviation of neuropathic pain by regulating T-type calcium channels in rat anterior cingulate cortex
por: Shen, Feng-Yan, et al.
Publicado: (2015)

Prognostic Significance of Maspin in Pancreatic Ductal Adenocarcinoma
por: Lim, Yun Jeong, et al.
Publicado: (2004)

Enhanced T-type calcium channel 3.2 activity in sensory neurons contributes to neuropathic-like pain of monosodium iodoacetate-induced knee osteoarthritis
por: Shin, Seung Min, et al.
Publicado: (2020)

Clinical outcomes between calcium channel blockers and angiotensin receptor blockers in hypertensive patients without established cardiovascular diseases during a 3-year follow-up
por: Jeong, Han Saem, et al.
Publicado: (2021)

Exploring the Binding Nature of Pyrrolidine Pocket-Dependent Interactions in the Polo-Box Domain of Polo-Like Kinase 1
por: Murugan, Ravichandran N., et al.
Publicado: (2013)

Intracellular Loop in the Brain Isoforms of Anoctamin 2 Channels Regulates Calcium-dependent Activation
por: Lee, Dongsu, et al.
Publicado: (2023)

Three-Dimensional Image Transmission of Integral Imaging through Wireless MIMO Channel
por: Lim, Seung-Chan, et al.
Publicado: (2023)

Comparison of olecranon osteotomy and paratricipital approach in distal humerus intra-articular fracture: A systematic review and meta-analysis
por: Jeong, Ho-Seung, et al.
Publicado: (2022)

Synthesis and Biological Evaluation of Disubstituted Pyrimidines as Selective 5-HT(2C) Agonists
por: Kim, Juhyeon, et al.
Publicado: (2019)

Antioxidant and Anti-Inflammatory Activities of a Natural Compound, Shizukahenriol, through Nrf2 Activation
por: Park, Jong-Hyun, et al.
Publicado: (2015)

A Low Concentration of Citreoviridin Prevents Both Intracellular Calcium Deposition in Vascular Smooth Muscle Cell and Osteoclast Activation In Vitro
por: Jeong, Seongtae, et al.
Publicado: (2023)

Autoimmune hemolytic anemia predominantly associated with IgA anti-E and anti-c.
por: Lim, Young Ae, et al.
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_6omrn1vv2vcvp9cu3tjpktmsrv