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Serum Albumin Binding and Esterase Activity: Mechanistic Interactions with Organophosphates

The albumin molecule, in contrast to many other plasma proteins, is not covered with a carbohydrate moiety and can bind and transport various molecules of endogenous and exogenous origin. The enzymatic activity of albumin, the existence of which many scientists perceive skeptically, is much less stu...

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Autores principales: Goncharov, Nikolay V., Belinskaia, Daria A., Shmurak, Vladimir I., Terpilowski, Maxim A., Jenkins, Richard O., Avdonin, Pavel V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151986/
https://www.ncbi.nlm.nih.gov/pubmed/28718803
http://dx.doi.org/10.3390/molecules22071201
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author Goncharov, Nikolay V.
Belinskaia, Daria A.
Shmurak, Vladimir I.
Terpilowski, Maxim A.
Jenkins, Richard O.
Avdonin, Pavel V.
author_facet Goncharov, Nikolay V.
Belinskaia, Daria A.
Shmurak, Vladimir I.
Terpilowski, Maxim A.
Jenkins, Richard O.
Avdonin, Pavel V.
author_sort Goncharov, Nikolay V.
collection PubMed
description The albumin molecule, in contrast to many other plasma proteins, is not covered with a carbohydrate moiety and can bind and transport various molecules of endogenous and exogenous origin. The enzymatic activity of albumin, the existence of which many scientists perceive skeptically, is much less studied. In toxicology, understanding the mechanistic interactions of organophosphates with albumin is a special problem, and its solution could help in the development of new types of antidotes. In the present work, the history of the issue is briefly examined, then our in silico data on the interaction of human serum albumin with soman, as well as comparative in silico data of human and bovine serum albumin activities in relation to paraoxon, are presented. Information is given on the substrate specificity of albumin and we consider the possibility of its affiliation to certain classes in the nomenclature of enzymes.
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spelling pubmed-61519862018-11-13 Serum Albumin Binding and Esterase Activity: Mechanistic Interactions with Organophosphates Goncharov, Nikolay V. Belinskaia, Daria A. Shmurak, Vladimir I. Terpilowski, Maxim A. Jenkins, Richard O. Avdonin, Pavel V. Molecules Article The albumin molecule, in contrast to many other plasma proteins, is not covered with a carbohydrate moiety and can bind and transport various molecules of endogenous and exogenous origin. The enzymatic activity of albumin, the existence of which many scientists perceive skeptically, is much less studied. In toxicology, understanding the mechanistic interactions of organophosphates with albumin is a special problem, and its solution could help in the development of new types of antidotes. In the present work, the history of the issue is briefly examined, then our in silico data on the interaction of human serum albumin with soman, as well as comparative in silico data of human and bovine serum albumin activities in relation to paraoxon, are presented. Information is given on the substrate specificity of albumin and we consider the possibility of its affiliation to certain classes in the nomenclature of enzymes. MDPI 2017-07-18 /pmc/articles/PMC6151986/ /pubmed/28718803 http://dx.doi.org/10.3390/molecules22071201 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Goncharov, Nikolay V.
Belinskaia, Daria A.
Shmurak, Vladimir I.
Terpilowski, Maxim A.
Jenkins, Richard O.
Avdonin, Pavel V.
Serum Albumin Binding and Esterase Activity: Mechanistic Interactions with Organophosphates
title Serum Albumin Binding and Esterase Activity: Mechanistic Interactions with Organophosphates
title_full Serum Albumin Binding and Esterase Activity: Mechanistic Interactions with Organophosphates
title_fullStr Serum Albumin Binding and Esterase Activity: Mechanistic Interactions with Organophosphates
title_full_unstemmed Serum Albumin Binding and Esterase Activity: Mechanistic Interactions with Organophosphates
title_short Serum Albumin Binding and Esterase Activity: Mechanistic Interactions with Organophosphates
title_sort serum albumin binding and esterase activity: mechanistic interactions with organophosphates
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151986/
https://www.ncbi.nlm.nih.gov/pubmed/28718803
http://dx.doi.org/10.3390/molecules22071201
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