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Analytical Techniques and Pharmacokinetics of Gastrodia elata Blume and Its Constituents
Gastrodia elata Blume (G. elata), commonly called Tianma in Chinese, is an important and notable traditional Chinese medicine (TCM), which has been used in China as an anticonvulsant, analgesic, sedative, anti-asthma, anti-immune drug since ancient times. The aim of this review is to provide an over...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152015/ https://www.ncbi.nlm.nih.gov/pubmed/28698450 http://dx.doi.org/10.3390/molecules22071137 |
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author | Wu, Jinyi Wu, Bingchu Tang, Chunlan Zhao, Jinshun |
author_facet | Wu, Jinyi Wu, Bingchu Tang, Chunlan Zhao, Jinshun |
author_sort | Wu, Jinyi |
collection | PubMed |
description | Gastrodia elata Blume (G. elata), commonly called Tianma in Chinese, is an important and notable traditional Chinese medicine (TCM), which has been used in China as an anticonvulsant, analgesic, sedative, anti-asthma, anti-immune drug since ancient times. The aim of this review is to provide an overview of the abundant efforts of scientists in developing analytical techniques and performing pharmacokinetic studies of G. elata and its constituents, including sample pretreatment methods, analytical techniques, absorption, distribution, metabolism, excretion (ADME) and influence factors to its pharmacokinetics. Based on the reported pharmacokinetic property data of G. elata and its constituents, it is hoped that more studies will focus on the development of rapid and sensitive analytical techniques, discovering new therapeutic uses and understanding the specific in vivo mechanisms of action of G. elata and its constituents from the pharmacokinetic viewpoint in the near future. The present review discusses analytical techniques and pharmacokinetics of G. elata and its constituents reported from 1985 onwards. |
format | Online Article Text |
id | pubmed-6152015 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61520152018-11-13 Analytical Techniques and Pharmacokinetics of Gastrodia elata Blume and Its Constituents Wu, Jinyi Wu, Bingchu Tang, Chunlan Zhao, Jinshun Molecules Review Gastrodia elata Blume (G. elata), commonly called Tianma in Chinese, is an important and notable traditional Chinese medicine (TCM), which has been used in China as an anticonvulsant, analgesic, sedative, anti-asthma, anti-immune drug since ancient times. The aim of this review is to provide an overview of the abundant efforts of scientists in developing analytical techniques and performing pharmacokinetic studies of G. elata and its constituents, including sample pretreatment methods, analytical techniques, absorption, distribution, metabolism, excretion (ADME) and influence factors to its pharmacokinetics. Based on the reported pharmacokinetic property data of G. elata and its constituents, it is hoped that more studies will focus on the development of rapid and sensitive analytical techniques, discovering new therapeutic uses and understanding the specific in vivo mechanisms of action of G. elata and its constituents from the pharmacokinetic viewpoint in the near future. The present review discusses analytical techniques and pharmacokinetics of G. elata and its constituents reported from 1985 onwards. MDPI 2017-07-08 /pmc/articles/PMC6152015/ /pubmed/28698450 http://dx.doi.org/10.3390/molecules22071137 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wu, Jinyi Wu, Bingchu Tang, Chunlan Zhao, Jinshun Analytical Techniques and Pharmacokinetics of Gastrodia elata Blume and Its Constituents |
title | Analytical Techniques and Pharmacokinetics of Gastrodia elata Blume and Its Constituents |
title_full | Analytical Techniques and Pharmacokinetics of Gastrodia elata Blume and Its Constituents |
title_fullStr | Analytical Techniques and Pharmacokinetics of Gastrodia elata Blume and Its Constituents |
title_full_unstemmed | Analytical Techniques and Pharmacokinetics of Gastrodia elata Blume and Its Constituents |
title_short | Analytical Techniques and Pharmacokinetics of Gastrodia elata Blume and Its Constituents |
title_sort | analytical techniques and pharmacokinetics of gastrodia elata blume and its constituents |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152015/ https://www.ncbi.nlm.nih.gov/pubmed/28698450 http://dx.doi.org/10.3390/molecules22071137 |
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