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Analytical Techniques and Pharmacokinetics of Gastrodia elata Blume and Its Constituents

Gastrodia elata Blume (G. elata), commonly called Tianma in Chinese, is an important and notable traditional Chinese medicine (TCM), which has been used in China as an anticonvulsant, analgesic, sedative, anti-asthma, anti-immune drug since ancient times. The aim of this review is to provide an over...

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Autores principales: Wu, Jinyi, Wu, Bingchu, Tang, Chunlan, Zhao, Jinshun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152015/
https://www.ncbi.nlm.nih.gov/pubmed/28698450
http://dx.doi.org/10.3390/molecules22071137
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author Wu, Jinyi
Wu, Bingchu
Tang, Chunlan
Zhao, Jinshun
author_facet Wu, Jinyi
Wu, Bingchu
Tang, Chunlan
Zhao, Jinshun
author_sort Wu, Jinyi
collection PubMed
description Gastrodia elata Blume (G. elata), commonly called Tianma in Chinese, is an important and notable traditional Chinese medicine (TCM), which has been used in China as an anticonvulsant, analgesic, sedative, anti-asthma, anti-immune drug since ancient times. The aim of this review is to provide an overview of the abundant efforts of scientists in developing analytical techniques and performing pharmacokinetic studies of G. elata and its constituents, including sample pretreatment methods, analytical techniques, absorption, distribution, metabolism, excretion (ADME) and influence factors to its pharmacokinetics. Based on the reported pharmacokinetic property data of G. elata and its constituents, it is hoped that more studies will focus on the development of rapid and sensitive analytical techniques, discovering new therapeutic uses and understanding the specific in vivo mechanisms of action of G. elata and its constituents from the pharmacokinetic viewpoint in the near future. The present review discusses analytical techniques and pharmacokinetics of G. elata and its constituents reported from 1985 onwards.
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spelling pubmed-61520152018-11-13 Analytical Techniques and Pharmacokinetics of Gastrodia elata Blume and Its Constituents Wu, Jinyi Wu, Bingchu Tang, Chunlan Zhao, Jinshun Molecules Review Gastrodia elata Blume (G. elata), commonly called Tianma in Chinese, is an important and notable traditional Chinese medicine (TCM), which has been used in China as an anticonvulsant, analgesic, sedative, anti-asthma, anti-immune drug since ancient times. The aim of this review is to provide an overview of the abundant efforts of scientists in developing analytical techniques and performing pharmacokinetic studies of G. elata and its constituents, including sample pretreatment methods, analytical techniques, absorption, distribution, metabolism, excretion (ADME) and influence factors to its pharmacokinetics. Based on the reported pharmacokinetic property data of G. elata and its constituents, it is hoped that more studies will focus on the development of rapid and sensitive analytical techniques, discovering new therapeutic uses and understanding the specific in vivo mechanisms of action of G. elata and its constituents from the pharmacokinetic viewpoint in the near future. The present review discusses analytical techniques and pharmacokinetics of G. elata and its constituents reported from 1985 onwards. MDPI 2017-07-08 /pmc/articles/PMC6152015/ /pubmed/28698450 http://dx.doi.org/10.3390/molecules22071137 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wu, Jinyi
Wu, Bingchu
Tang, Chunlan
Zhao, Jinshun
Analytical Techniques and Pharmacokinetics of Gastrodia elata Blume and Its Constituents
title Analytical Techniques and Pharmacokinetics of Gastrodia elata Blume and Its Constituents
title_full Analytical Techniques and Pharmacokinetics of Gastrodia elata Blume and Its Constituents
title_fullStr Analytical Techniques and Pharmacokinetics of Gastrodia elata Blume and Its Constituents
title_full_unstemmed Analytical Techniques and Pharmacokinetics of Gastrodia elata Blume and Its Constituents
title_short Analytical Techniques and Pharmacokinetics of Gastrodia elata Blume and Its Constituents
title_sort analytical techniques and pharmacokinetics of gastrodia elata blume and its constituents
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152015/
https://www.ncbi.nlm.nih.gov/pubmed/28698450
http://dx.doi.org/10.3390/molecules22071137
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