Cargando…

Studies on the Two Thymine Residues in the Catalytic Core of 10-23 DNAzyme: The Impact on the Catalysis of Their 5-Substituted Functional Groups

In the 15-mer catalytic core of 10-23 DNAzyme, each residue contributes to the catalytic conformation differently. Here, the critically conserved T4 and the least conserved T8 were modified on their 5-position with hydroxyl, imidazolyl, and amino groups with a hydrogen-bonding ability. These externa...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Pengyu, Du, Shanshan, Li, Yang, He, Junlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152017/
https://www.ncbi.nlm.nih.gov/pubmed/28640218
http://dx.doi.org/10.3390/molecules22071011