Cargando…

Molecular Docking and Anticonvulsant Activity of Newly Synthesized Quinazoline Derivatives

A new series of quinazoline-4(3H)-ones are evaluated for anticonvulsant activity. After intraperitoneal (ip) injection to albino mice at a dose of 100 mg/kg body weight, synthesized quinazolin-4(3H)-ones (1–24) were examined in the maximal electroshock (MES) induced seizures and subcutaneous pentyle...

Descripción completa

Detalles Bibliográficos
Autores principales:	Abuelizz, Hatem A., El Dib, Rabab, Marzouk, Mohamed, Anouar, El-Hassane, Maklad, Yousreya A., Attia, Hanan N., Al-Salahi, Rashad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152033/ https://www.ncbi.nlm.nih.gov/pubmed/28665338 http://dx.doi.org/10.3390/molecules22071094

Ejemplares similares

Molecular docking study and antiviral evaluation of 2-thioxo-benzo[g]quinazolin-4(3H)-one derivatives
por: Al-Salahi, Rashad, et al.
Publicado: (2016)

Synthesis and anticancer activity of new quinazoline derivatives
por: Abuelizz, Hatem A., et al.
Publicado: (2017)

Investigation of some benzoquinazoline and quinazoline derivatives as novel inhibitors of HCV-NS3/4A protease: biological, molecular docking and QSAR studies
por: Abuelizz, Hatem A., et al.
Publicado: (2020)

Synthesis, biological activity and molecular docking of new tricyclic series as α-glucosidase inhibitors
por: Abuelizz, Hatem A., et al.
Publicado: (2019)

Triazoloquinazolines as a new class of potent α-glucosidase inhibitors: in vitro evaluation and docking study
por: Abuelizz, Hatem A., et al.
Publicado: (2019)

Radioiodination and biodistribution of newly synthesized 3-benzyl-2-([3-methoxybenzyl]thio)benzo[g]quinazolin-4-(3H)-one in tumor bearing mice
por: Al-Salahi, Rashad, et al.
Publicado: (2018)

Investigation the antioxidant activity of benzo[g]triazoloquinazolines correlated with a DFT study
por: Almehizia, Abdulrahman A., et al.
Publicado: (2019)

Evaluation of Some Benzo[g]Quinazoline Derivatives as Antiviral Agents against Human Rotavirus Wa Strain: Biological Screening and Docking Study
por: Abuelizz, Hatem A., et al.
Publicado: (2023)

Antiviral activity of some benzo[g]quinazolines against coxsackievirus B4: biological screening and docking study
por: Abuelizz, Hatem A., et al.
Publicado: (2023)

Benzo[g]quinazolines as antifungal against candidiasis: Screening, molecular docking, and QSAR investigations
por: Abuelizz, Hatem A., et al.
Publicado: (2023)

Antiproliferative and Antiangiogenic Properties of New VEGFR-2-targeting 2-thioxobenzo[g]quinazoline Derivatives (In Vitro)
por: Abuelizz, Hatem A., et al.
Publicado: (2020)

Biological Investigation of 2-Thioxo-benzo[g]quinazolines against Adenovirus Type 7 and Bacteriophage Phi X174: An In Vitro Study
por: Abuelizz, Hatem A., et al.
Publicado: (2023)

Anticonvulsant Potential of Certain New (2E)-2-[1-Aryl-3-(1H-imidazol-1-yl)propylidene]-N-(aryl/H)hydrazinecarboxamides
por: Attia, Mohamed I., et al.
Publicado: (2014)

Reactivity of 4,5-Dichlorophthalic Anhydride towards Thiosemicarbazide and Amines: Synthesis, Spectroscopic Analysis, and DFT Study
por: Abuelizz, Hatem A., et al.
Publicado: (2022)

5-Chloro-2-methylsulfonyl-1,2,4-triazolo[1,5-a]quinazoline
por: Al-Salahi, Rashad, et al.
Publicado: (2012)

Synthesis and Reactivity of [1,2,4]Triazolo-annelated Quinazolines
por: Al-Salahi, Rashad A.
Publicado: (2010)

Investigation of 4-Hydrazinobenzoic Acid Derivatives for Their Antioxidant Activity: In Vitro Screening and DFT Study
por: Abuelizz, Hatem A., et al.
Publicado: (2021)

Biological effects of a new set 1,2,4-triazolo[1,5-a]quinazolines on heart rate and blood pressure
por: Al-Salahi, Rashad, et al.
Publicado: (2014)

2-Methylsulfonyl-1,2,4-triazolo[1,5-a]quinazolin-5(4H)-one
por: Al-Salahi, Rashad, et al.
Publicado: (2012)

Synthesis and Anticonvulsant Activity of Some Quinazolin-4-(3H)-one Derivatives
por: Georgey, Hanan, et al.
Publicado: (2008)

Anticonvulsant Profiles of Certain New 6-Aryl-9-substituted-6,9-diazaspiro-[4.5]decane-8,10-diones and 1-Aryl-4-substituted-1,4-diazaspiro[5.5]undecane-3,5-diones
por: Aboul-Enein, Mohamed N., et al.
Publicado: (2014)

2-Methylsulfanyl-1,2,4-triazolo[1,5-a]quinazoline-5(4H)-thione
por: Al-Salahi, Rashad, et al.
Publicado: (2013)

Synthesis, crystallographic characterization, molecular docking and biological activity of isoquinoline derivatives
por: Abuelizz, Hatem A., et al.
Publicado: (2017)

3-Benzyl-8-methoxy-2-sulfanylidene-1,2,3,4-tetrahydroquinazolin-4-one
por: Al-Salahi, Rashad, et al.
Publicado: (2012)

3-(Prop-2-en-1-yl)-2-sulfanylidene-1,2,3,4-tetrahydroquinazolin-4-one
por: Al-Salahi, Rashad, et al.
Publicado: (2012)

Cytotoxicity of Newly Synthesized Quinazoline–Sulfonamide Derivatives in Human Leukemia Cell Lines and Their Effect on Hematopoiesis in Zebrafish Embryos
por: Alqahtani, Ali S., et al.
Publicado: (2022)

Multidimensional insights involving electrochemical and in silico investigation into the corrosion inhibition of newly synthesized pyrazolotriazole derivatives on carbon steel in a HCl solution
por: Guo, Lei, et al.
Publicado: (2019)

Synthesis and biological evaluation of 4-(1H-1,2,4-triazol-1-yl)benzoic acid hybrids as anticancer agents
por: Abuelizz, Hatem A., et al.
Publicado: (2019)

Al-Salahi, R. Synthesis and Reactivity of [1,2,4]Triazolo-annelated Quinazolines. Molecules 2010, 15, 7016–7034
por: Al-Salahi, Rashad A., et al.
Publicado: (2010)

Biochemical characterization, anti-inflammatory properties and ulcerogenic traits of some cold-pressed oils in experimental animals
por: Ibrahim, Faten M., et al.
Publicado: (2017)

Docking and Antiherpetic Activity of 2-Aminobenzo[de]-isoquinoline-1,3-diones
por: Al-Salahi, Rashad, et al.
Publicado: (2015)

2-Benzyloxy-1,2,4-triazolo[1,5-a]quinazolin-5(4H)-one
por: Al-Salahi, Rashad, et al.
Publicado: (2011)

2-Benzyloxy-1,2,4-triazolo[1,5-a]quinazolin-5(4H)-one. Corrigendum
por: Al-Salahi, Rashad, et al.
Publicado: (2011)

2-Ethoxy-5-methylbis[1,2,4]triazolo[1,5-a:4′,3′-c]quinazoline
por: Al-Salahi, Rashad, et al.
Publicado: (2011)

2-Methylsulfanyl-1,2,4-triazolo[1,5-a]quinazolin-5(4H)-one
por: Al-Salahi, Rashad, et al.
Publicado: (2012)

2-Phenoxy-1,2,4-triazolo[1,5-a]quinazolin-5(4H)-one
por: Al-Salahi, Rashad, et al.
Publicado: (2012)

Synthesis, Modelling, and Anticonvulsant Studies of New Quinazolines Showing Three Highly Active Compounds with Low Toxicity and High Affinity to the GABA-A Receptor
por: Zayed, Mohamed F., et al.
Publicado: (2017)

Synthesis, Biological Evaluation and Docking Analysis of Some Novel Quinazolin Derivatives as Antitumor Agents
por: El-serwy, Walaa S., et al.
Publicado: (2016)

Synthesis, Molecular Docking and In Vitro Screening of Some Newly Synthesized Triazolopyridine, Pyridotriazine and Pyridine–Pyrazole Hybrid Derivatives
por: Flefel, Eman M., et al.
Publicado: (2018)

Fabrication and In Vitro Biological Assay of Thermo-Mechanically Tuned Chitosan Reinforced Polyurethane Composites
por: Akram, Nadia, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_dvr5p6273aind286i4mptm3i15