Isolation and Characterization of Aphidicolin Derivatives from Tolypocladium inflatum

Inflatin G (1), a new aphidicolin analogue, together with seven known compounds inflatin A (2), inflatin B (3), aphidicolin (4), aphidicolin-17-monoacetate (5), gulypyrone A (6), pyridoxatin rotamers A (7) and B (8), were isolated from the ascomycete fungus Tolypocladium inflatum. Their structures w...

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Detalles Bibliográficos
Autores principales: Lin, Jie, Niu, Shubin, Ding, Zhengfeng, Wang, Renlei, Dai, Qun, Wei, Wei, Luo, Rongrong, Liu, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152040/
https://www.ncbi.nlm.nih.gov/pubmed/28704971
http://dx.doi.org/10.3390/molecules22071168
Descripción
Sumario:Inflatin G (1), a new aphidicolin analogue, together with seven known compounds inflatin A (2), inflatin B (3), aphidicolin (4), aphidicolin-17-monoacetate (5), gulypyrone A (6), pyridoxatin rotamers A (7) and B (8), were isolated from the ascomycete fungus Tolypocladium inflatum. Their structures were determined through NMR analyses and the circular dichroism data of the in situ formed [Rh(2)(OCOCF(3))(4)] complexes. Compounds 1, 4, 5, 7, and 8 showed modest cytotoxicity against four human cancer cell lines A549, CNE1-MP1, A375, and MCF-7.

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