Isolation and Characterization of Aphidicolin Derivatives from Tolypocladium inflatum

Inflatin G (1), a new aphidicolin analogue, together with seven known compounds inflatin A (2), inflatin B (3), aphidicolin (4), aphidicolin-17-monoacetate (5), gulypyrone A (6), pyridoxatin rotamers A (7) and B (8), were isolated from the ascomycete fungus Tolypocladium inflatum. Their structures w...

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Autores principales: Lin, Jie, Niu, Shubin, Ding, Zhengfeng, Wang, Renlei, Dai, Qun, Wei, Wei, Luo, Rongrong, Liu, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152040/
https://www.ncbi.nlm.nih.gov/pubmed/28704971
http://dx.doi.org/10.3390/molecules22071168
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author Lin, Jie
Niu, Shubin
Ding, Zhengfeng
Wang, Renlei
Dai, Qun
Wei, Wei
Luo, Rongrong
Liu, Ling
author_facet Lin, Jie
Niu, Shubin
Ding, Zhengfeng
Wang, Renlei
Dai, Qun
Wei, Wei
Luo, Rongrong
Liu, Ling
author_sort Lin, Jie
collection PubMed
description Inflatin G (1), a new aphidicolin analogue, together with seven known compounds inflatin A (2), inflatin B (3), aphidicolin (4), aphidicolin-17-monoacetate (5), gulypyrone A (6), pyridoxatin rotamers A (7) and B (8), were isolated from the ascomycete fungus Tolypocladium inflatum. Their structures were determined through NMR analyses and the circular dichroism data of the in situ formed [Rh(2)(OCOCF(3))(4)] complexes. Compounds 1, 4, 5, 7, and 8 showed modest cytotoxicity against four human cancer cell lines A549, CNE1-MP1, A375, and MCF-7.
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spelling pubmed-61520402018-11-13 Isolation and Characterization of Aphidicolin Derivatives from Tolypocladium inflatum Lin, Jie Niu, Shubin Ding, Zhengfeng Wang, Renlei Dai, Qun Wei, Wei Luo, Rongrong Liu, Ling Molecules Article Inflatin G (1), a new aphidicolin analogue, together with seven known compounds inflatin A (2), inflatin B (3), aphidicolin (4), aphidicolin-17-monoacetate (5), gulypyrone A (6), pyridoxatin rotamers A (7) and B (8), were isolated from the ascomycete fungus Tolypocladium inflatum. Their structures were determined through NMR analyses and the circular dichroism data of the in situ formed [Rh(2)(OCOCF(3))(4)] complexes. Compounds 1, 4, 5, 7, and 8 showed modest cytotoxicity against four human cancer cell lines A549, CNE1-MP1, A375, and MCF-7. MDPI 2017-07-12 /pmc/articles/PMC6152040/ /pubmed/28704971 http://dx.doi.org/10.3390/molecules22071168 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lin, Jie
Niu, Shubin
Ding, Zhengfeng
Wang, Renlei
Dai, Qun
Wei, Wei
Luo, Rongrong
Liu, Ling
Isolation and Characterization of Aphidicolin Derivatives from Tolypocladium inflatum
title Isolation and Characterization of Aphidicolin Derivatives from Tolypocladium inflatum
title_full Isolation and Characterization of Aphidicolin Derivatives from Tolypocladium inflatum
title_fullStr Isolation and Characterization of Aphidicolin Derivatives from Tolypocladium inflatum
title_full_unstemmed Isolation and Characterization of Aphidicolin Derivatives from Tolypocladium inflatum
title_short Isolation and Characterization of Aphidicolin Derivatives from Tolypocladium inflatum
title_sort isolation and characterization of aphidicolin derivatives from tolypocladium inflatum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152040/
https://www.ncbi.nlm.nih.gov/pubmed/28704971
http://dx.doi.org/10.3390/molecules22071168
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