An Efficient Synthesis of Arylated Pyridines from Conjugated Acetylenes and Substituted Benzylamines Catalyzed by Base

An efficient base-catalyzed synthesis of arylated pyridines has been disclosed. This reaction involving conjugated acetylenes and substituted benzylamines proceeded smoothly, giving rise to tri-aryl substituted pyridines which are biologically relevant compounds in good to excellent yields in N,N-di...

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Detalles Bibliográficos
Autores principales: Guo, Mengping, Chen, Bo, Zhu, Qiming, Jin, Hua, Peng, Qiuling, Kang, Yanping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152059/
https://www.ncbi.nlm.nih.gov/pubmed/28758981
http://dx.doi.org/10.3390/molecules22081277
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author Guo, Mengping
Chen, Bo
Zhu, Qiming
Jin, Hua
Peng, Qiuling
Kang, Yanping
author_facet Guo, Mengping
Chen, Bo
Zhu, Qiming
Jin, Hua
Peng, Qiuling
Kang, Yanping
author_sort Guo, Mengping
collection PubMed
description An efficient base-catalyzed synthesis of arylated pyridines has been disclosed. This reaction involving conjugated acetylenes and substituted benzylamines proceeded smoothly, giving rise to tri-aryl substituted pyridines which are biologically relevant compounds in good to excellent yields in N,N-dimethylformamide (DMF) under air at 140 °C with K(2)CO(3) as catalyst.
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spelling pubmed-61520592018-11-13 An Efficient Synthesis of Arylated Pyridines from Conjugated Acetylenes and Substituted Benzylamines Catalyzed by Base Guo, Mengping Chen, Bo Zhu, Qiming Jin, Hua Peng, Qiuling Kang, Yanping Molecules Communication An efficient base-catalyzed synthesis of arylated pyridines has been disclosed. This reaction involving conjugated acetylenes and substituted benzylamines proceeded smoothly, giving rise to tri-aryl substituted pyridines which are biologically relevant compounds in good to excellent yields in N,N-dimethylformamide (DMF) under air at 140 °C with K(2)CO(3) as catalyst. MDPI 2017-07-31 /pmc/articles/PMC6152059/ /pubmed/28758981 http://dx.doi.org/10.3390/molecules22081277 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Guo, Mengping
Chen, Bo
Zhu, Qiming
Jin, Hua
Peng, Qiuling
Kang, Yanping
An Efficient Synthesis of Arylated Pyridines from Conjugated Acetylenes and Substituted Benzylamines Catalyzed by Base
title An Efficient Synthesis of Arylated Pyridines from Conjugated Acetylenes and Substituted Benzylamines Catalyzed by Base
title_full An Efficient Synthesis of Arylated Pyridines from Conjugated Acetylenes and Substituted Benzylamines Catalyzed by Base
title_fullStr An Efficient Synthesis of Arylated Pyridines from Conjugated Acetylenes and Substituted Benzylamines Catalyzed by Base
title_full_unstemmed An Efficient Synthesis of Arylated Pyridines from Conjugated Acetylenes and Substituted Benzylamines Catalyzed by Base
title_short An Efficient Synthesis of Arylated Pyridines from Conjugated Acetylenes and Substituted Benzylamines Catalyzed by Base
title_sort efficient synthesis of arylated pyridines from conjugated acetylenes and substituted benzylamines catalyzed by base
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152059/
https://www.ncbi.nlm.nih.gov/pubmed/28758981
http://dx.doi.org/10.3390/molecules22081277
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