Albumin and Hyaluronic Acid-Coated Superparamagnetic Iron Oxide Nanoparticles Loaded with Paclitaxel for Biomedical Applications

Super paramagnetic iron oxide nanoparticles (SPION) were augmented by both hyaluronic acid (HA) and bovine serum albumin (BSA), each covalently conjugated to dopamine (DA) enabling their anchoring to the SPION. HA and BSA were found to simultaneously serve as stabilizing polymers of Fe(3)O(4)·DA-BSA...

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Autores principales: Vismara, Elena, Bongio, Chiara, Coletti, Alessia, Edelman, Ravit, Serafini, Andrea, Mauri, Michele, Simonutti, Roberto, Bertini, Sabrina, Urso, Elena, Assaraf, Yehuda G., Livney, Yoav D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152103/
https://www.ncbi.nlm.nih.gov/pubmed/28640222
http://dx.doi.org/10.3390/molecules22071030
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author Vismara, Elena
Bongio, Chiara
Coletti, Alessia
Edelman, Ravit
Serafini, Andrea
Mauri, Michele
Simonutti, Roberto
Bertini, Sabrina
Urso, Elena
Assaraf, Yehuda G.
Livney, Yoav D.
author_facet Vismara, Elena
Bongio, Chiara
Coletti, Alessia
Edelman, Ravit
Serafini, Andrea
Mauri, Michele
Simonutti, Roberto
Bertini, Sabrina
Urso, Elena
Assaraf, Yehuda G.
Livney, Yoav D.
author_sort Vismara, Elena
collection PubMed
description Super paramagnetic iron oxide nanoparticles (SPION) were augmented by both hyaluronic acid (HA) and bovine serum albumin (BSA), each covalently conjugated to dopamine (DA) enabling their anchoring to the SPION. HA and BSA were found to simultaneously serve as stabilizing polymers of Fe(3)O(4)·DA-BSA/HA in water. Fe(3)O(4)·DA-BSA/HA efficiently entrapped and released the hydrophobic cytotoxic drug paclitaxel (PTX). The relative amount of HA and BSA modulates not only the total solubility but also the paramagnetic relaxation properties of the preparation. The entrapping of PTX did not influence the paramagnetic relaxation properties of Fe(3)O(4)·DA-BSA. Thus, by tuning the surface structure and loading, we can tune the theranostic properties of the system.
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spelling pubmed-61521032018-11-13 Albumin and Hyaluronic Acid-Coated Superparamagnetic Iron Oxide Nanoparticles Loaded with Paclitaxel for Biomedical Applications Vismara, Elena Bongio, Chiara Coletti, Alessia Edelman, Ravit Serafini, Andrea Mauri, Michele Simonutti, Roberto Bertini, Sabrina Urso, Elena Assaraf, Yehuda G. Livney, Yoav D. Molecules Article Super paramagnetic iron oxide nanoparticles (SPION) were augmented by both hyaluronic acid (HA) and bovine serum albumin (BSA), each covalently conjugated to dopamine (DA) enabling their anchoring to the SPION. HA and BSA were found to simultaneously serve as stabilizing polymers of Fe(3)O(4)·DA-BSA/HA in water. Fe(3)O(4)·DA-BSA/HA efficiently entrapped and released the hydrophobic cytotoxic drug paclitaxel (PTX). The relative amount of HA and BSA modulates not only the total solubility but also the paramagnetic relaxation properties of the preparation. The entrapping of PTX did not influence the paramagnetic relaxation properties of Fe(3)O(4)·DA-BSA. Thus, by tuning the surface structure and loading, we can tune the theranostic properties of the system. MDPI 2017-06-22 /pmc/articles/PMC6152103/ /pubmed/28640222 http://dx.doi.org/10.3390/molecules22071030 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vismara, Elena
Bongio, Chiara
Coletti, Alessia
Edelman, Ravit
Serafini, Andrea
Mauri, Michele
Simonutti, Roberto
Bertini, Sabrina
Urso, Elena
Assaraf, Yehuda G.
Livney, Yoav D.
Albumin and Hyaluronic Acid-Coated Superparamagnetic Iron Oxide Nanoparticles Loaded with Paclitaxel for Biomedical Applications
title Albumin and Hyaluronic Acid-Coated Superparamagnetic Iron Oxide Nanoparticles Loaded with Paclitaxel for Biomedical Applications
title_full Albumin and Hyaluronic Acid-Coated Superparamagnetic Iron Oxide Nanoparticles Loaded with Paclitaxel for Biomedical Applications
title_fullStr Albumin and Hyaluronic Acid-Coated Superparamagnetic Iron Oxide Nanoparticles Loaded with Paclitaxel for Biomedical Applications
title_full_unstemmed Albumin and Hyaluronic Acid-Coated Superparamagnetic Iron Oxide Nanoparticles Loaded with Paclitaxel for Biomedical Applications
title_short Albumin and Hyaluronic Acid-Coated Superparamagnetic Iron Oxide Nanoparticles Loaded with Paclitaxel for Biomedical Applications
title_sort albumin and hyaluronic acid-coated superparamagnetic iron oxide nanoparticles loaded with paclitaxel for biomedical applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152103/
https://www.ncbi.nlm.nih.gov/pubmed/28640222
http://dx.doi.org/10.3390/molecules22071030
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