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Community outbreak of serogroup B invasive meningococcal disease in Beaujolais, France, February to June 2016: from alert to targeted vaccination

In February and March 2016, four cases of serogroup B invasive meningococcal disease (IMD) occurred over 3 weeks in a small area north of Lyon in the Auvergne-Rhône-Alpes region, France. There were no deaths but two cases had sequelae. This community outbreak was caused by a rare meningococcal strai...

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Autores principales: Thabuis, Alexandra, Tararbit, Karim, Taha, Muhamed-Kheir, Dejour-Salamanca, Dominique, Ronin, Vincent, Parent du Chatelet, Isabelle, Spaccaferri, Guillaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152148/
https://www.ncbi.nlm.nih.gov/pubmed/30017022
http://dx.doi.org/10.2807/1560-7917.ES.2018.23.28.1700590
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author Thabuis, Alexandra
Tararbit, Karim
Taha, Muhamed-Kheir
Dejour-Salamanca, Dominique
Ronin, Vincent
Parent du Chatelet, Isabelle
Spaccaferri, Guillaume
author_facet Thabuis, Alexandra
Tararbit, Karim
Taha, Muhamed-Kheir
Dejour-Salamanca, Dominique
Ronin, Vincent
Parent du Chatelet, Isabelle
Spaccaferri, Guillaume
author_sort Thabuis, Alexandra
collection PubMed
description In February and March 2016, four cases of serogroup B invasive meningococcal disease (IMD) occurred over 3 weeks in a small area north of Lyon in the Auvergne-Rhône-Alpes region, France. There were no deaths but two cases had sequelae. This community outbreak was caused by a rare meningococcal strain of the clonal complex ST-32, covered by the 4CMenB/Bexsero vaccine. The incidence rate for serogroup B IMD in this area was 22.5 per 100,000 inhabitants, which is above the epidemic threshold (10/100,000). The number of cases observed was significantly higher than expected in the age group of 0–24 year-olds (standardised incidence ratio: 96). These results suggested the potential emergence of this invasive strain in this sub-population. In accordance with French recommendations, it was decided to vaccinate the population aged between 2 months and 24 years, living, working or studying in the epidemic area. The vaccination campaign took place from April to September 2016. Vaccination coverage was estimated at 47% for one dose and 40% for two doses. The lowest coverage estimations were observed for the age groups younger than 3 and 15–19 years. Enhanced epidemiological and microbiological surveillance reported a fifth case in June 2016, outside the epidemic area.
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spelling pubmed-61521482018-10-12 Community outbreak of serogroup B invasive meningococcal disease in Beaujolais, France, February to June 2016: from alert to targeted vaccination Thabuis, Alexandra Tararbit, Karim Taha, Muhamed-Kheir Dejour-Salamanca, Dominique Ronin, Vincent Parent du Chatelet, Isabelle Spaccaferri, Guillaume Euro Surveill Surveillance and Outbreak Report In February and March 2016, four cases of serogroup B invasive meningococcal disease (IMD) occurred over 3 weeks in a small area north of Lyon in the Auvergne-Rhône-Alpes region, France. There were no deaths but two cases had sequelae. This community outbreak was caused by a rare meningococcal strain of the clonal complex ST-32, covered by the 4CMenB/Bexsero vaccine. The incidence rate for serogroup B IMD in this area was 22.5 per 100,000 inhabitants, which is above the epidemic threshold (10/100,000). The number of cases observed was significantly higher than expected in the age group of 0–24 year-olds (standardised incidence ratio: 96). These results suggested the potential emergence of this invasive strain in this sub-population. In accordance with French recommendations, it was decided to vaccinate the population aged between 2 months and 24 years, living, working or studying in the epidemic area. The vaccination campaign took place from April to September 2016. Vaccination coverage was estimated at 47% for one dose and 40% for two doses. The lowest coverage estimations were observed for the age groups younger than 3 and 15–19 years. Enhanced epidemiological and microbiological surveillance reported a fifth case in June 2016, outside the epidemic area. European Centre for Disease Prevention and Control (ECDC) 2018-07-12 /pmc/articles/PMC6152148/ /pubmed/30017022 http://dx.doi.org/10.2807/1560-7917.ES.2018.23.28.1700590 Text en This article is copyright of The Authors, 2018. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Surveillance and Outbreak Report
Thabuis, Alexandra
Tararbit, Karim
Taha, Muhamed-Kheir
Dejour-Salamanca, Dominique
Ronin, Vincent
Parent du Chatelet, Isabelle
Spaccaferri, Guillaume
Community outbreak of serogroup B invasive meningococcal disease in Beaujolais, France, February to June 2016: from alert to targeted vaccination
title Community outbreak of serogroup B invasive meningococcal disease in Beaujolais, France, February to June 2016: from alert to targeted vaccination
title_full Community outbreak of serogroup B invasive meningococcal disease in Beaujolais, France, February to June 2016: from alert to targeted vaccination
title_fullStr Community outbreak of serogroup B invasive meningococcal disease in Beaujolais, France, February to June 2016: from alert to targeted vaccination
title_full_unstemmed Community outbreak of serogroup B invasive meningococcal disease in Beaujolais, France, February to June 2016: from alert to targeted vaccination
title_short Community outbreak of serogroup B invasive meningococcal disease in Beaujolais, France, February to June 2016: from alert to targeted vaccination
title_sort community outbreak of serogroup b invasive meningococcal disease in beaujolais, france, february to june 2016: from alert to targeted vaccination
topic Surveillance and Outbreak Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152148/
https://www.ncbi.nlm.nih.gov/pubmed/30017022
http://dx.doi.org/10.2807/1560-7917.ES.2018.23.28.1700590
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