Trehalose Inhibits A53T Mutant α-Synuclein Overexpression and Neurotoxicity in Transduced PC12 Cells

Fibrillar accumulation of A53T mutant α-synuclein (A53T-AS) in Lewy bodies is a symptom of Parkinsonism. Inhibitions of the overexpression and fibrillar aggregation of α-synuclein (AS) in vivo could be a promising strategy for treating Parkinson’s disease (PD). In this study, at concentrations lower...

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Autores principales: Zhao, Juan, Zhi, Xiuling, Pan, Luanfeng, Zhou, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152154/
https://www.ncbi.nlm.nih.gov/pubmed/28786917
http://dx.doi.org/10.3390/molecules22081293
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author Zhao, Juan
Zhi, Xiuling
Pan, Luanfeng
Zhou, Ping
author_facet Zhao, Juan
Zhi, Xiuling
Pan, Luanfeng
Zhou, Ping
author_sort Zhao, Juan
collection PubMed
description Fibrillar accumulation of A53T mutant α-synuclein (A53T-AS) in Lewy bodies is a symptom of Parkinsonism. Inhibitions of the overexpression and fibrillar aggregation of α-synuclein (AS) in vivo could be a promising strategy for treating Parkinson’s disease (PD). In this study, at concentrations lower than 1 mM, trehalose decreased the A53T-AS expression level in transduced PC12 cells. Although H(2)O(2) and aluminum ions increased the expression level and neurotoxicity of A53T-AS in cells, proper trehalose concentrations inhibited the event. These studies adequately prove that trehalose at an appropriate dose would be potentially useful for PD treatment.
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spelling pubmed-61521542018-11-13 Trehalose Inhibits A53T Mutant α-Synuclein Overexpression and Neurotoxicity in Transduced PC12 Cells Zhao, Juan Zhi, Xiuling Pan, Luanfeng Zhou, Ping Molecules Article Fibrillar accumulation of A53T mutant α-synuclein (A53T-AS) in Lewy bodies is a symptom of Parkinsonism. Inhibitions of the overexpression and fibrillar aggregation of α-synuclein (AS) in vivo could be a promising strategy for treating Parkinson’s disease (PD). In this study, at concentrations lower than 1 mM, trehalose decreased the A53T-AS expression level in transduced PC12 cells. Although H(2)O(2) and aluminum ions increased the expression level and neurotoxicity of A53T-AS in cells, proper trehalose concentrations inhibited the event. These studies adequately prove that trehalose at an appropriate dose would be potentially useful for PD treatment. MDPI 2017-08-08 /pmc/articles/PMC6152154/ /pubmed/28786917 http://dx.doi.org/10.3390/molecules22081293 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhao, Juan
Zhi, Xiuling
Pan, Luanfeng
Zhou, Ping
Trehalose Inhibits A53T Mutant α-Synuclein Overexpression and Neurotoxicity in Transduced PC12 Cells
title Trehalose Inhibits A53T Mutant α-Synuclein Overexpression and Neurotoxicity in Transduced PC12 Cells
title_full Trehalose Inhibits A53T Mutant α-Synuclein Overexpression and Neurotoxicity in Transduced PC12 Cells
title_fullStr Trehalose Inhibits A53T Mutant α-Synuclein Overexpression and Neurotoxicity in Transduced PC12 Cells
title_full_unstemmed Trehalose Inhibits A53T Mutant α-Synuclein Overexpression and Neurotoxicity in Transduced PC12 Cells
title_short Trehalose Inhibits A53T Mutant α-Synuclein Overexpression and Neurotoxicity in Transduced PC12 Cells
title_sort trehalose inhibits a53t mutant α-synuclein overexpression and neurotoxicity in transduced pc12 cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152154/
https://www.ncbi.nlm.nih.gov/pubmed/28786917
http://dx.doi.org/10.3390/molecules22081293
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