Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018

We describe a gonorrhoea case with combined high-level azithromycin resistance and ceftriaxone resistance. In February 2018, a heterosexual male was diagnosed with gonorrhoea in the United Kingdom following sexual intercourse with a locally resident female in Thailand and failed treatment with ceftr...

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Autores principales: Eyre, David W, Sanderson, Nicholas D, Lord, Emily, Regisford-Reimmer, Natasha, Chau, Kevin, Barker, Leanne, Morgan, Markus, Newnham, Robert, Golparian, Daniel, Unemo, Magnus, Crook, Derrick W, Peto, Tim EA, Hughes, Gwenda, Cole, Michelle J, Fifer, Helen, Edwards, Anne, Andersson, Monique I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2018
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152157/
https://www.ncbi.nlm.nih.gov/pubmed/29991383
http://dx.doi.org/10.2807/1560-7917.ES.2018.23.27.1800323
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author Eyre, David W
Sanderson, Nicholas D
Lord, Emily
Regisford-Reimmer, Natasha
Chau, Kevin
Barker, Leanne
Morgan, Markus
Newnham, Robert
Golparian, Daniel
Unemo, Magnus
Crook, Derrick W
Peto, Tim EA
Hughes, Gwenda
Cole, Michelle J
Fifer, Helen
Edwards, Anne
Andersson, Monique I
author_facet Eyre, David W
Sanderson, Nicholas D
Lord, Emily
Regisford-Reimmer, Natasha
Chau, Kevin
Barker, Leanne
Morgan, Markus
Newnham, Robert
Golparian, Daniel
Unemo, Magnus
Crook, Derrick W
Peto, Tim EA
Hughes, Gwenda
Cole, Michelle J
Fifer, Helen
Edwards, Anne
Andersson, Monique I
author_sort Eyre, David W
collection PubMed
description We describe a gonorrhoea case with combined high-level azithromycin resistance and ceftriaxone resistance. In February 2018, a heterosexual male was diagnosed with gonorrhoea in the United Kingdom following sexual intercourse with a locally resident female in Thailand and failed treatment with ceftriaxone plus doxycycline and subsequently spectinomycin. Resistance arose from two mechanisms combining for the first time in a genetic background similar to a commonly circulating strain. Urgent action is essential to prevent further spread.
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spelling pubmed-61521572018-10-12 Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018 Eyre, David W Sanderson, Nicholas D Lord, Emily Regisford-Reimmer, Natasha Chau, Kevin Barker, Leanne Morgan, Markus Newnham, Robert Golparian, Daniel Unemo, Magnus Crook, Derrick W Peto, Tim EA Hughes, Gwenda Cole, Michelle J Fifer, Helen Edwards, Anne Andersson, Monique I Euro Surveill Rapid Communication We describe a gonorrhoea case with combined high-level azithromycin resistance and ceftriaxone resistance. In February 2018, a heterosexual male was diagnosed with gonorrhoea in the United Kingdom following sexual intercourse with a locally resident female in Thailand and failed treatment with ceftriaxone plus doxycycline and subsequently spectinomycin. Resistance arose from two mechanisms combining for the first time in a genetic background similar to a commonly circulating strain. Urgent action is essential to prevent further spread. European Centre for Disease Prevention and Control (ECDC) 2018-07-05 /pmc/articles/PMC6152157/ /pubmed/29991383 http://dx.doi.org/10.2807/1560-7917.ES.2018.23.27.1800323 Text en This article is copyright of The Authors, 2018. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Rapid Communication
Eyre, David W
Sanderson, Nicholas D
Lord, Emily
Regisford-Reimmer, Natasha
Chau, Kevin
Barker, Leanne
Morgan, Markus
Newnham, Robert
Golparian, Daniel
Unemo, Magnus
Crook, Derrick W
Peto, Tim EA
Hughes, Gwenda
Cole, Michelle J
Fifer, Helen
Edwards, Anne
Andersson, Monique I
Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018
title Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018
title_full Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018
title_fullStr Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018
title_full_unstemmed Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018
title_short Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018
title_sort gonorrhoea treatment failure caused by a neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, england, february 2018
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152157/
https://www.ncbi.nlm.nih.gov/pubmed/29991383
http://dx.doi.org/10.2807/1560-7917.ES.2018.23.27.1800323
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