A Novel Brominated Alkaloid Securidine A, Isolated from the Marine Bryozoan Securiflustra securifrons

A novel brominated alkaloid, Securidine A, was isolated from the cold water marine bryozoan Securiflustra securifrons. Securidine A was isolated using semi-preparative HPLC, and the structure was elucidated by spectroscopic methods. The isolated Securidine A was tested for cytotoxic, antibacterial,...

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Autores principales: Michael, Priyanka, Hansen, Kine Ø., Isaksson, Johan, Andersen, Jeanette H., Hansen, Espen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152195/
https://www.ncbi.nlm.nih.gov/pubmed/28737700
http://dx.doi.org/10.3390/molecules22071236
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author Michael, Priyanka
Hansen, Kine Ø.
Isaksson, Johan
Andersen, Jeanette H.
Hansen, Espen
author_facet Michael, Priyanka
Hansen, Kine Ø.
Isaksson, Johan
Andersen, Jeanette H.
Hansen, Espen
author_sort Michael, Priyanka
collection PubMed
description A novel brominated alkaloid, Securidine A, was isolated from the cold water marine bryozoan Securiflustra securifrons. Securidine A was isolated using semi-preparative HPLC, and the structure was elucidated by spectroscopic methods. The isolated Securidine A was tested for cytotoxic, antibacterial, and anti-diabetic activities as well as for its potential for inhibition of biofilm formation. No significant biological activity was observed in the applied bioassays, thus expanded bioactivity profiling is required, in order to reveal any potential applications for Securidine A.
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spelling pubmed-61521952018-11-13 A Novel Brominated Alkaloid Securidine A, Isolated from the Marine Bryozoan Securiflustra securifrons Michael, Priyanka Hansen, Kine Ø. Isaksson, Johan Andersen, Jeanette H. Hansen, Espen Molecules Article A novel brominated alkaloid, Securidine A, was isolated from the cold water marine bryozoan Securiflustra securifrons. Securidine A was isolated using semi-preparative HPLC, and the structure was elucidated by spectroscopic methods. The isolated Securidine A was tested for cytotoxic, antibacterial, and anti-diabetic activities as well as for its potential for inhibition of biofilm formation. No significant biological activity was observed in the applied bioassays, thus expanded bioactivity profiling is required, in order to reveal any potential applications for Securidine A. MDPI 2017-07-23 /pmc/articles/PMC6152195/ /pubmed/28737700 http://dx.doi.org/10.3390/molecules22071236 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Michael, Priyanka
Hansen, Kine Ø.
Isaksson, Johan
Andersen, Jeanette H.
Hansen, Espen
A Novel Brominated Alkaloid Securidine A, Isolated from the Marine Bryozoan Securiflustra securifrons
title A Novel Brominated Alkaloid Securidine A, Isolated from the Marine Bryozoan Securiflustra securifrons
title_full A Novel Brominated Alkaloid Securidine A, Isolated from the Marine Bryozoan Securiflustra securifrons
title_fullStr A Novel Brominated Alkaloid Securidine A, Isolated from the Marine Bryozoan Securiflustra securifrons
title_full_unstemmed A Novel Brominated Alkaloid Securidine A, Isolated from the Marine Bryozoan Securiflustra securifrons
title_short A Novel Brominated Alkaloid Securidine A, Isolated from the Marine Bryozoan Securiflustra securifrons
title_sort novel brominated alkaloid securidine a, isolated from the marine bryozoan securiflustra securifrons
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152195/
https://www.ncbi.nlm.nih.gov/pubmed/28737700
http://dx.doi.org/10.3390/molecules22071236
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