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A Novel Brominated Alkaloid Securidine A, Isolated from the Marine Bryozoan Securiflustra securifrons
A novel brominated alkaloid, Securidine A, was isolated from the cold water marine bryozoan Securiflustra securifrons. Securidine A was isolated using semi-preparative HPLC, and the structure was elucidated by spectroscopic methods. The isolated Securidine A was tested for cytotoxic, antibacterial,...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152195/ https://www.ncbi.nlm.nih.gov/pubmed/28737700 http://dx.doi.org/10.3390/molecules22071236 |
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author | Michael, Priyanka Hansen, Kine Ø. Isaksson, Johan Andersen, Jeanette H. Hansen, Espen |
author_facet | Michael, Priyanka Hansen, Kine Ø. Isaksson, Johan Andersen, Jeanette H. Hansen, Espen |
author_sort | Michael, Priyanka |
collection | PubMed |
description | A novel brominated alkaloid, Securidine A, was isolated from the cold water marine bryozoan Securiflustra securifrons. Securidine A was isolated using semi-preparative HPLC, and the structure was elucidated by spectroscopic methods. The isolated Securidine A was tested for cytotoxic, antibacterial, and anti-diabetic activities as well as for its potential for inhibition of biofilm formation. No significant biological activity was observed in the applied bioassays, thus expanded bioactivity profiling is required, in order to reveal any potential applications for Securidine A. |
format | Online Article Text |
id | pubmed-6152195 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61521952018-11-13 A Novel Brominated Alkaloid Securidine A, Isolated from the Marine Bryozoan Securiflustra securifrons Michael, Priyanka Hansen, Kine Ø. Isaksson, Johan Andersen, Jeanette H. Hansen, Espen Molecules Article A novel brominated alkaloid, Securidine A, was isolated from the cold water marine bryozoan Securiflustra securifrons. Securidine A was isolated using semi-preparative HPLC, and the structure was elucidated by spectroscopic methods. The isolated Securidine A was tested for cytotoxic, antibacterial, and anti-diabetic activities as well as for its potential for inhibition of biofilm formation. No significant biological activity was observed in the applied bioassays, thus expanded bioactivity profiling is required, in order to reveal any potential applications for Securidine A. MDPI 2017-07-23 /pmc/articles/PMC6152195/ /pubmed/28737700 http://dx.doi.org/10.3390/molecules22071236 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Michael, Priyanka Hansen, Kine Ø. Isaksson, Johan Andersen, Jeanette H. Hansen, Espen A Novel Brominated Alkaloid Securidine A, Isolated from the Marine Bryozoan Securiflustra securifrons |
title | A Novel Brominated Alkaloid Securidine A, Isolated from the Marine Bryozoan Securiflustra securifrons |
title_full | A Novel Brominated Alkaloid Securidine A, Isolated from the Marine Bryozoan Securiflustra securifrons |
title_fullStr | A Novel Brominated Alkaloid Securidine A, Isolated from the Marine Bryozoan Securiflustra securifrons |
title_full_unstemmed | A Novel Brominated Alkaloid Securidine A, Isolated from the Marine Bryozoan Securiflustra securifrons |
title_short | A Novel Brominated Alkaloid Securidine A, Isolated from the Marine Bryozoan Securiflustra securifrons |
title_sort | novel brominated alkaloid securidine a, isolated from the marine bryozoan securiflustra securifrons |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152195/ https://www.ncbi.nlm.nih.gov/pubmed/28737700 http://dx.doi.org/10.3390/molecules22071236 |
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