A New Approach to Synthesize of 4-Phenacylideneflavene Derivatives and to Evaluate Their Cytotoxic Effects on HepG2 Cell Line

In this study, a convenient approach and green procedure for the synthesis of 4-phenacylideneflavenes has been developed from the reaction between 2,4-dihydroxybenzaldehyde and substituted acetophenones using boric acid as a catalyst in polyethylene glycol 400. Seven 4-phenacylideneflavenes were syn...

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Detalles Bibliográficos
Autores principales: Chen, Hongbin, Xu, Yang, Zhang, Yinan, Zheng, Zongping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152225/
https://www.ncbi.nlm.nih.gov/pubmed/28792431
http://dx.doi.org/10.3390/molecules22081296
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author Chen, Hongbin
Xu, Yang
Zhang, Yinan
Zheng, Zongping
author_facet Chen, Hongbin
Xu, Yang
Zhang, Yinan
Zheng, Zongping
author_sort Chen, Hongbin
collection PubMed
description In this study, a convenient approach and green procedure for the synthesis of 4-phenacylideneflavenes has been developed from the reaction between 2,4-dihydroxybenzaldehyde and substituted acetophenones using boric acid as a catalyst in polyethylene glycol 400. Seven 4-phenacylideneflavenes were synthetized and their structures were confirmed by NMR and mass spectral analyses. Meanwhile, their possible mechanism of formation was also discussed. These products were found to have potential cytotoxic effect on HepG2 cell line with IC(50) values from 12.5 to 50 µM.
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spelling pubmed-61522252018-11-13 A New Approach to Synthesize of 4-Phenacylideneflavene Derivatives and to Evaluate Their Cytotoxic Effects on HepG2 Cell Line Chen, Hongbin Xu, Yang Zhang, Yinan Zheng, Zongping Molecules Article In this study, a convenient approach and green procedure for the synthesis of 4-phenacylideneflavenes has been developed from the reaction between 2,4-dihydroxybenzaldehyde and substituted acetophenones using boric acid as a catalyst in polyethylene glycol 400. Seven 4-phenacylideneflavenes were synthetized and their structures were confirmed by NMR and mass spectral analyses. Meanwhile, their possible mechanism of formation was also discussed. These products were found to have potential cytotoxic effect on HepG2 cell line with IC(50) values from 12.5 to 50 µM. MDPI 2017-08-09 /pmc/articles/PMC6152225/ /pubmed/28792431 http://dx.doi.org/10.3390/molecules22081296 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Hongbin
Xu, Yang
Zhang, Yinan
Zheng, Zongping
A New Approach to Synthesize of 4-Phenacylideneflavene Derivatives and to Evaluate Their Cytotoxic Effects on HepG2 Cell Line
title A New Approach to Synthesize of 4-Phenacylideneflavene Derivatives and to Evaluate Their Cytotoxic Effects on HepG2 Cell Line
title_full A New Approach to Synthesize of 4-Phenacylideneflavene Derivatives and to Evaluate Their Cytotoxic Effects on HepG2 Cell Line
title_fullStr A New Approach to Synthesize of 4-Phenacylideneflavene Derivatives and to Evaluate Their Cytotoxic Effects on HepG2 Cell Line
title_full_unstemmed A New Approach to Synthesize of 4-Phenacylideneflavene Derivatives and to Evaluate Their Cytotoxic Effects on HepG2 Cell Line
title_short A New Approach to Synthesize of 4-Phenacylideneflavene Derivatives and to Evaluate Their Cytotoxic Effects on HepG2 Cell Line
title_sort new approach to synthesize of 4-phenacylideneflavene derivatives and to evaluate their cytotoxic effects on hepg2 cell line
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152225/
https://www.ncbi.nlm.nih.gov/pubmed/28792431
http://dx.doi.org/10.3390/molecules22081296
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