An Efficient Synthesis of Spiro[indoline-3,9′-xanthene]trione Derivatives Catalyzed by Magnesium Perchlorate

A simple and efficient method for the synthesis of spiro[indoline-3,9′-xanthene]trione derivatives by means of condensation between isatins and 1,3-cyclohexanedione in the presence of a catalytic amount of magnesium perchlorate at 80 °C in 50% aqueous ethanol medium has been described. Notably, the...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Chunfeng, Lv, Chunlei, Liang, Jianfeng, Jin, Jianqing, Wang, Lijun, Wu, Chunlei, Shen, Runpu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152258/
https://www.ncbi.nlm.nih.gov/pubmed/28777350
http://dx.doi.org/10.3390/molecules22081295
_version_ 1783357329020813312
author Chen, Chunfeng
Lv, Chunlei
Liang, Jianfeng
Jin, Jianqing
Wang, Lijun
Wu, Chunlei
Shen, Runpu
author_facet Chen, Chunfeng
Lv, Chunlei
Liang, Jianfeng
Jin, Jianqing
Wang, Lijun
Wu, Chunlei
Shen, Runpu
author_sort Chen, Chunfeng
collection PubMed
description A simple and efficient method for the synthesis of spiro[indoline-3,9′-xanthene]trione derivatives by means of condensation between isatins and 1,3-cyclohexanedione in the presence of a catalytic amount of magnesium perchlorate at 80 °C in 50% aqueous ethanol medium has been described. Notably, the present method offers desirable advantages of good yields, simplicity of workup procedure, easy purification, and reduced reaction times.
format Online
Article
Text
id pubmed-6152258
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-61522582018-11-13 An Efficient Synthesis of Spiro[indoline-3,9′-xanthene]trione Derivatives Catalyzed by Magnesium Perchlorate Chen, Chunfeng Lv, Chunlei Liang, Jianfeng Jin, Jianqing Wang, Lijun Wu, Chunlei Shen, Runpu Molecules Article A simple and efficient method for the synthesis of spiro[indoline-3,9′-xanthene]trione derivatives by means of condensation between isatins and 1,3-cyclohexanedione in the presence of a catalytic amount of magnesium perchlorate at 80 °C in 50% aqueous ethanol medium has been described. Notably, the present method offers desirable advantages of good yields, simplicity of workup procedure, easy purification, and reduced reaction times. MDPI 2017-08-04 /pmc/articles/PMC6152258/ /pubmed/28777350 http://dx.doi.org/10.3390/molecules22081295 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Chunfeng
Lv, Chunlei
Liang, Jianfeng
Jin, Jianqing
Wang, Lijun
Wu, Chunlei
Shen, Runpu
An Efficient Synthesis of Spiro[indoline-3,9′-xanthene]trione Derivatives Catalyzed by Magnesium Perchlorate
title An Efficient Synthesis of Spiro[indoline-3,9′-xanthene]trione Derivatives Catalyzed by Magnesium Perchlorate
title_full An Efficient Synthesis of Spiro[indoline-3,9′-xanthene]trione Derivatives Catalyzed by Magnesium Perchlorate
title_fullStr An Efficient Synthesis of Spiro[indoline-3,9′-xanthene]trione Derivatives Catalyzed by Magnesium Perchlorate
title_full_unstemmed An Efficient Synthesis of Spiro[indoline-3,9′-xanthene]trione Derivatives Catalyzed by Magnesium Perchlorate
title_short An Efficient Synthesis of Spiro[indoline-3,9′-xanthene]trione Derivatives Catalyzed by Magnesium Perchlorate
title_sort efficient synthesis of spiro[indoline-3,9′-xanthene]trione derivatives catalyzed by magnesium perchlorate
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152258/
https://www.ncbi.nlm.nih.gov/pubmed/28777350
http://dx.doi.org/10.3390/molecules22081295
work_keys_str_mv AT chenchunfeng anefficientsynthesisofspiroindoline39xanthenetrionederivativescatalyzedbymagnesiumperchlorate
AT lvchunlei anefficientsynthesisofspiroindoline39xanthenetrionederivativescatalyzedbymagnesiumperchlorate
AT liangjianfeng anefficientsynthesisofspiroindoline39xanthenetrionederivativescatalyzedbymagnesiumperchlorate
AT jinjianqing anefficientsynthesisofspiroindoline39xanthenetrionederivativescatalyzedbymagnesiumperchlorate
AT wanglijun anefficientsynthesisofspiroindoline39xanthenetrionederivativescatalyzedbymagnesiumperchlorate
AT wuchunlei anefficientsynthesisofspiroindoline39xanthenetrionederivativescatalyzedbymagnesiumperchlorate
AT shenrunpu anefficientsynthesisofspiroindoline39xanthenetrionederivativescatalyzedbymagnesiumperchlorate
AT chenchunfeng efficientsynthesisofspiroindoline39xanthenetrionederivativescatalyzedbymagnesiumperchlorate
AT lvchunlei efficientsynthesisofspiroindoline39xanthenetrionederivativescatalyzedbymagnesiumperchlorate
AT liangjianfeng efficientsynthesisofspiroindoline39xanthenetrionederivativescatalyzedbymagnesiumperchlorate
AT jinjianqing efficientsynthesisofspiroindoline39xanthenetrionederivativescatalyzedbymagnesiumperchlorate
AT wanglijun efficientsynthesisofspiroindoline39xanthenetrionederivativescatalyzedbymagnesiumperchlorate
AT wuchunlei efficientsynthesisofspiroindoline39xanthenetrionederivativescatalyzedbymagnesiumperchlorate
AT shenrunpu efficientsynthesisofspiroindoline39xanthenetrionederivativescatalyzedbymagnesiumperchlorate

Ejemplares similares