Inhibitory Effect of Bovine Lactoferrin on Catechol-O-Methyltransferase

Lactoferrin (LF) is a well-known multifunctional protein. In this study, we report the inhibitory potency of bovine LF (bLF) on catechol-O-methyltransferase (COMT), which catalyzes methylation of catechol substrates. We found that bLF binds to and inhibits COMT using its N-terminal region. An N-term...

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Detalles Bibliográficos
Autores principales: Ikeda, Masayuki, Iijima, Hiroshi, Shinoda, Ichizo, Iwamoto, Hiroshi, Takeda, Yasuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152271/
https://www.ncbi.nlm.nih.gov/pubmed/28825621
http://dx.doi.org/10.3390/molecules22081373

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152271/
https://www.ncbi.nlm.nih.gov/pubmed/28825621
http://dx.doi.org/10.3390/molecules22081373

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