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Inhibitory Effect of Bovine Lactoferrin on Catechol-O-Methyltransferase
Lactoferrin (LF) is a well-known multifunctional protein. In this study, we report the inhibitory potency of bovine LF (bLF) on catechol-O-methyltransferase (COMT), which catalyzes methylation of catechol substrates. We found that bLF binds to and inhibits COMT using its N-terminal region. An N-term...
Autores principales: | Ikeda, Masayuki, Iijima, Hiroshi, Shinoda, Ichizo, Iwamoto, Hiroshi, Takeda, Yasuhiro |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152271/ https://www.ncbi.nlm.nih.gov/pubmed/28825621 http://dx.doi.org/10.3390/molecules22081373 |
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