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Adiponectin, Leptin, and Leptin Receptor in Obese Patients with Type 2 Diabetes Treated with Insulin Detemir

The aim of the present study is to quantitatively assess the expression of selected regulatory molecules, such as leptin, leptin receptor, and adiponectin in the blood of obese patients with type 2 diabetes both before treatment and after six months of pharmacological therapy with the long-lasting i...

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Autores principales: Olczyk, Paweł, Koprowski, Robert, Komosinska-Vassev, Katarzyna, Jura-Półtorak, Agnieszka, Winsz-Szczotka, Katarzyna, Kuźnik-Trocha, Kornelia, Mencner, Łukasz, Telega, Alicja, Ivanova, Diana, Olczyk, Krystyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152287/
https://www.ncbi.nlm.nih.gov/pubmed/28758947
http://dx.doi.org/10.3390/molecules22081274
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author Olczyk, Paweł
Koprowski, Robert
Komosinska-Vassev, Katarzyna
Jura-Półtorak, Agnieszka
Winsz-Szczotka, Katarzyna
Kuźnik-Trocha, Kornelia
Mencner, Łukasz
Telega, Alicja
Ivanova, Diana
Olczyk, Krystyna
author_facet Olczyk, Paweł
Koprowski, Robert
Komosinska-Vassev, Katarzyna
Jura-Półtorak, Agnieszka
Winsz-Szczotka, Katarzyna
Kuźnik-Trocha, Kornelia
Mencner, Łukasz
Telega, Alicja
Ivanova, Diana
Olczyk, Krystyna
author_sort Olczyk, Paweł
collection PubMed
description The aim of the present study is to quantitatively assess the expression of selected regulatory molecules, such as leptin, leptin receptor, and adiponectin in the blood of obese patients with type 2 diabetes both before treatment and after six months of pharmacological therapy with the long-lasting insulin analogue, insulin detemir. A significant decrease in the analysed regulatory molecules, i.e., leptin receptor and adiponectin, was found in blood plasma of the patients with untreated type 2 diabetes. These changes were accompanied by an increase in plasma leptin concentrations. Insulin treatment resulted in the normalization of plasma leptin receptor and adiponectin concentrations. The circulating leptin level did not change following anti-diabetic therapy with insulin detemir. Gender was a significant factor modifying the circulating level of all the analysed regulatory active compounds. Bioinformatic analysis was performed using Matlab with the Signal Processing Toolbox. The conducted discriminant analysis revealed that the leptin receptor, Δw(19), and adiponectin, Δw(21), were the parameters undergoing the most significant quantitative changes during the six-month therapy with insulin detemir. The conducted examinations indicated the contribution of adipocytokines—the biologically-active mediators of systemic metabolism, such as leptin and adiponectin in the pathomechanism of disorders being the basis for obesity which leads to development of insulin resistance, which, in turn, results in the occurrence of type 2 diabetes.
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spelling pubmed-61522872018-11-13 Adiponectin, Leptin, and Leptin Receptor in Obese Patients with Type 2 Diabetes Treated with Insulin Detemir Olczyk, Paweł Koprowski, Robert Komosinska-Vassev, Katarzyna Jura-Półtorak, Agnieszka Winsz-Szczotka, Katarzyna Kuźnik-Trocha, Kornelia Mencner, Łukasz Telega, Alicja Ivanova, Diana Olczyk, Krystyna Molecules Article The aim of the present study is to quantitatively assess the expression of selected regulatory molecules, such as leptin, leptin receptor, and adiponectin in the blood of obese patients with type 2 diabetes both before treatment and after six months of pharmacological therapy with the long-lasting insulin analogue, insulin detemir. A significant decrease in the analysed regulatory molecules, i.e., leptin receptor and adiponectin, was found in blood plasma of the patients with untreated type 2 diabetes. These changes were accompanied by an increase in plasma leptin concentrations. Insulin treatment resulted in the normalization of plasma leptin receptor and adiponectin concentrations. The circulating leptin level did not change following anti-diabetic therapy with insulin detemir. Gender was a significant factor modifying the circulating level of all the analysed regulatory active compounds. Bioinformatic analysis was performed using Matlab with the Signal Processing Toolbox. The conducted discriminant analysis revealed that the leptin receptor, Δw(19), and adiponectin, Δw(21), were the parameters undergoing the most significant quantitative changes during the six-month therapy with insulin detemir. The conducted examinations indicated the contribution of adipocytokines—the biologically-active mediators of systemic metabolism, such as leptin and adiponectin in the pathomechanism of disorders being the basis for obesity which leads to development of insulin resistance, which, in turn, results in the occurrence of type 2 diabetes. MDPI 2017-07-30 /pmc/articles/PMC6152287/ /pubmed/28758947 http://dx.doi.org/10.3390/molecules22081274 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Olczyk, Paweł
Koprowski, Robert
Komosinska-Vassev, Katarzyna
Jura-Półtorak, Agnieszka
Winsz-Szczotka, Katarzyna
Kuźnik-Trocha, Kornelia
Mencner, Łukasz
Telega, Alicja
Ivanova, Diana
Olczyk, Krystyna
Adiponectin, Leptin, and Leptin Receptor in Obese Patients with Type 2 Diabetes Treated with Insulin Detemir
title Adiponectin, Leptin, and Leptin Receptor in Obese Patients with Type 2 Diabetes Treated with Insulin Detemir
title_full Adiponectin, Leptin, and Leptin Receptor in Obese Patients with Type 2 Diabetes Treated with Insulin Detemir
title_fullStr Adiponectin, Leptin, and Leptin Receptor in Obese Patients with Type 2 Diabetes Treated with Insulin Detemir
title_full_unstemmed Adiponectin, Leptin, and Leptin Receptor in Obese Patients with Type 2 Diabetes Treated with Insulin Detemir
title_short Adiponectin, Leptin, and Leptin Receptor in Obese Patients with Type 2 Diabetes Treated with Insulin Detemir
title_sort adiponectin, leptin, and leptin receptor in obese patients with type 2 diabetes treated with insulin detemir
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152287/
https://www.ncbi.nlm.nih.gov/pubmed/28758947
http://dx.doi.org/10.3390/molecules22081274
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