Cargando…
Adiponectin, Leptin, and Leptin Receptor in Obese Patients with Type 2 Diabetes Treated with Insulin Detemir
The aim of the present study is to quantitatively assess the expression of selected regulatory molecules, such as leptin, leptin receptor, and adiponectin in the blood of obese patients with type 2 diabetes both before treatment and after six months of pharmacological therapy with the long-lasting i...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152287/ https://www.ncbi.nlm.nih.gov/pubmed/28758947 http://dx.doi.org/10.3390/molecules22081274 |
_version_ | 1783357335811391488 |
---|---|
author | Olczyk, Paweł Koprowski, Robert Komosinska-Vassev, Katarzyna Jura-Półtorak, Agnieszka Winsz-Szczotka, Katarzyna Kuźnik-Trocha, Kornelia Mencner, Łukasz Telega, Alicja Ivanova, Diana Olczyk, Krystyna |
author_facet | Olczyk, Paweł Koprowski, Robert Komosinska-Vassev, Katarzyna Jura-Półtorak, Agnieszka Winsz-Szczotka, Katarzyna Kuźnik-Trocha, Kornelia Mencner, Łukasz Telega, Alicja Ivanova, Diana Olczyk, Krystyna |
author_sort | Olczyk, Paweł |
collection | PubMed |
description | The aim of the present study is to quantitatively assess the expression of selected regulatory molecules, such as leptin, leptin receptor, and adiponectin in the blood of obese patients with type 2 diabetes both before treatment and after six months of pharmacological therapy with the long-lasting insulin analogue, insulin detemir. A significant decrease in the analysed regulatory molecules, i.e., leptin receptor and adiponectin, was found in blood plasma of the patients with untreated type 2 diabetes. These changes were accompanied by an increase in plasma leptin concentrations. Insulin treatment resulted in the normalization of plasma leptin receptor and adiponectin concentrations. The circulating leptin level did not change following anti-diabetic therapy with insulin detemir. Gender was a significant factor modifying the circulating level of all the analysed regulatory active compounds. Bioinformatic analysis was performed using Matlab with the Signal Processing Toolbox. The conducted discriminant analysis revealed that the leptin receptor, Δw(19), and adiponectin, Δw(21), were the parameters undergoing the most significant quantitative changes during the six-month therapy with insulin detemir. The conducted examinations indicated the contribution of adipocytokines—the biologically-active mediators of systemic metabolism, such as leptin and adiponectin in the pathomechanism of disorders being the basis for obesity which leads to development of insulin resistance, which, in turn, results in the occurrence of type 2 diabetes. |
format | Online Article Text |
id | pubmed-6152287 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61522872018-11-13 Adiponectin, Leptin, and Leptin Receptor in Obese Patients with Type 2 Diabetes Treated with Insulin Detemir Olczyk, Paweł Koprowski, Robert Komosinska-Vassev, Katarzyna Jura-Półtorak, Agnieszka Winsz-Szczotka, Katarzyna Kuźnik-Trocha, Kornelia Mencner, Łukasz Telega, Alicja Ivanova, Diana Olczyk, Krystyna Molecules Article The aim of the present study is to quantitatively assess the expression of selected regulatory molecules, such as leptin, leptin receptor, and adiponectin in the blood of obese patients with type 2 diabetes both before treatment and after six months of pharmacological therapy with the long-lasting insulin analogue, insulin detemir. A significant decrease in the analysed regulatory molecules, i.e., leptin receptor and adiponectin, was found in blood plasma of the patients with untreated type 2 diabetes. These changes were accompanied by an increase in plasma leptin concentrations. Insulin treatment resulted in the normalization of plasma leptin receptor and adiponectin concentrations. The circulating leptin level did not change following anti-diabetic therapy with insulin detemir. Gender was a significant factor modifying the circulating level of all the analysed regulatory active compounds. Bioinformatic analysis was performed using Matlab with the Signal Processing Toolbox. The conducted discriminant analysis revealed that the leptin receptor, Δw(19), and adiponectin, Δw(21), were the parameters undergoing the most significant quantitative changes during the six-month therapy with insulin detemir. The conducted examinations indicated the contribution of adipocytokines—the biologically-active mediators of systemic metabolism, such as leptin and adiponectin in the pathomechanism of disorders being the basis for obesity which leads to development of insulin resistance, which, in turn, results in the occurrence of type 2 diabetes. MDPI 2017-07-30 /pmc/articles/PMC6152287/ /pubmed/28758947 http://dx.doi.org/10.3390/molecules22081274 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Olczyk, Paweł Koprowski, Robert Komosinska-Vassev, Katarzyna Jura-Półtorak, Agnieszka Winsz-Szczotka, Katarzyna Kuźnik-Trocha, Kornelia Mencner, Łukasz Telega, Alicja Ivanova, Diana Olczyk, Krystyna Adiponectin, Leptin, and Leptin Receptor in Obese Patients with Type 2 Diabetes Treated with Insulin Detemir |
title | Adiponectin, Leptin, and Leptin Receptor in Obese Patients with Type 2 Diabetes Treated with Insulin Detemir |
title_full | Adiponectin, Leptin, and Leptin Receptor in Obese Patients with Type 2 Diabetes Treated with Insulin Detemir |
title_fullStr | Adiponectin, Leptin, and Leptin Receptor in Obese Patients with Type 2 Diabetes Treated with Insulin Detemir |
title_full_unstemmed | Adiponectin, Leptin, and Leptin Receptor in Obese Patients with Type 2 Diabetes Treated with Insulin Detemir |
title_short | Adiponectin, Leptin, and Leptin Receptor in Obese Patients with Type 2 Diabetes Treated with Insulin Detemir |
title_sort | adiponectin, leptin, and leptin receptor in obese patients with type 2 diabetes treated with insulin detemir |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152287/ https://www.ncbi.nlm.nih.gov/pubmed/28758947 http://dx.doi.org/10.3390/molecules22081274 |
work_keys_str_mv | AT olczykpaweł adiponectinleptinandleptinreceptorinobesepatientswithtype2diabetestreatedwithinsulindetemir AT koprowskirobert adiponectinleptinandleptinreceptorinobesepatientswithtype2diabetestreatedwithinsulindetemir AT komosinskavassevkatarzyna adiponectinleptinandleptinreceptorinobesepatientswithtype2diabetestreatedwithinsulindetemir AT jurapołtorakagnieszka adiponectinleptinandleptinreceptorinobesepatientswithtype2diabetestreatedwithinsulindetemir AT winszszczotkakatarzyna adiponectinleptinandleptinreceptorinobesepatientswithtype2diabetestreatedwithinsulindetemir AT kuzniktrochakornelia adiponectinleptinandleptinreceptorinobesepatientswithtype2diabetestreatedwithinsulindetemir AT mencnerłukasz adiponectinleptinandleptinreceptorinobesepatientswithtype2diabetestreatedwithinsulindetemir AT telegaalicja adiponectinleptinandleptinreceptorinobesepatientswithtype2diabetestreatedwithinsulindetemir AT ivanovadiana adiponectinleptinandleptinreceptorinobesepatientswithtype2diabetestreatedwithinsulindetemir AT olczykkrystyna adiponectinleptinandleptinreceptorinobesepatientswithtype2diabetestreatedwithinsulindetemir |