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Inositol Derivatives and Phenolic Compounds from the Roots of Taraxacum coreanum
In this study, the characterization of chemical constituents and biological activity of the roots of Taraxacum coreanum (Asteraceae) was attempted. Phytochemical investigation of the roots of T. coreanum led to the isolation of two new inositol derivatives, taraxinositols A (1) and B (2), and a new...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152297/ https://www.ncbi.nlm.nih.gov/pubmed/28805750 http://dx.doi.org/10.3390/molecules22081349 |
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author | Mo, Eun Jin Ahn, Jong Hoon Jo, Yang Hee Kim, Seon Beom Hwang, Bang Yeon Lee, Mi Kyeong |
author_facet | Mo, Eun Jin Ahn, Jong Hoon Jo, Yang Hee Kim, Seon Beom Hwang, Bang Yeon Lee, Mi Kyeong |
author_sort | Mo, Eun Jin |
collection | PubMed |
description | In this study, the characterization of chemical constituents and biological activity of the roots of Taraxacum coreanum (Asteraceae) was attempted. Phytochemical investigation of the roots of T. coreanum led to the isolation of two new inositol derivatives, taraxinositols A (1) and B (2), and a new phenolic compound, taraxinol (16), together with twenty known compounds including four inositol derivatives, neo-inositol-1,4-bis (4-hydroxybenzeneacetate) (3), chiro-inositol-1,5-bis(4- hydroxybenzeneacetate) (4), chiro-inositol-2,3-bis (4-hydroxybenzeneacetate) (5) and chiro-inositol- 1,2,3-tris (4-hydroxybenzeneacetate) (6), nine phenolic compounds: p-hydroxybenzaldehyde (7), vanillin (8), syringaldehyde (9), vanillic acid (10), 4-methoxyphenylacetic acid (11), 4-hydroxy- phenylacetic acid methyl ester (12), optivanin (13), isoferulic acid (14) and dihydroconiferyl alcohol (15), four coumarins: nodakenetin (17), decursinol (18), prangol (19) and isobyakangelicin (20), and three lignans: syringaresinol-4′-O-β-d-glucoside (21), syringaresinol (22), and pinoresinol (23). The structures of isolated compounds were determined on the basis of spectroscopic analysis. Among the isolated compounds, vanillic acid, isoferulic acid and syringaresinol showed radical scavenging activity with IC(50) values ranging from 30.4 to 75.2 μM. |
format | Online Article Text |
id | pubmed-6152297 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61522972018-11-13 Inositol Derivatives and Phenolic Compounds from the Roots of Taraxacum coreanum Mo, Eun Jin Ahn, Jong Hoon Jo, Yang Hee Kim, Seon Beom Hwang, Bang Yeon Lee, Mi Kyeong Molecules Article In this study, the characterization of chemical constituents and biological activity of the roots of Taraxacum coreanum (Asteraceae) was attempted. Phytochemical investigation of the roots of T. coreanum led to the isolation of two new inositol derivatives, taraxinositols A (1) and B (2), and a new phenolic compound, taraxinol (16), together with twenty known compounds including four inositol derivatives, neo-inositol-1,4-bis (4-hydroxybenzeneacetate) (3), chiro-inositol-1,5-bis(4- hydroxybenzeneacetate) (4), chiro-inositol-2,3-bis (4-hydroxybenzeneacetate) (5) and chiro-inositol- 1,2,3-tris (4-hydroxybenzeneacetate) (6), nine phenolic compounds: p-hydroxybenzaldehyde (7), vanillin (8), syringaldehyde (9), vanillic acid (10), 4-methoxyphenylacetic acid (11), 4-hydroxy- phenylacetic acid methyl ester (12), optivanin (13), isoferulic acid (14) and dihydroconiferyl alcohol (15), four coumarins: nodakenetin (17), decursinol (18), prangol (19) and isobyakangelicin (20), and three lignans: syringaresinol-4′-O-β-d-glucoside (21), syringaresinol (22), and pinoresinol (23). The structures of isolated compounds were determined on the basis of spectroscopic analysis. Among the isolated compounds, vanillic acid, isoferulic acid and syringaresinol showed radical scavenging activity with IC(50) values ranging from 30.4 to 75.2 μM. MDPI 2017-08-14 /pmc/articles/PMC6152297/ /pubmed/28805750 http://dx.doi.org/10.3390/molecules22081349 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mo, Eun Jin Ahn, Jong Hoon Jo, Yang Hee Kim, Seon Beom Hwang, Bang Yeon Lee, Mi Kyeong Inositol Derivatives and Phenolic Compounds from the Roots of Taraxacum coreanum |
title | Inositol Derivatives and Phenolic Compounds from the Roots of Taraxacum coreanum |
title_full | Inositol Derivatives and Phenolic Compounds from the Roots of Taraxacum coreanum |
title_fullStr | Inositol Derivatives and Phenolic Compounds from the Roots of Taraxacum coreanum |
title_full_unstemmed | Inositol Derivatives and Phenolic Compounds from the Roots of Taraxacum coreanum |
title_short | Inositol Derivatives and Phenolic Compounds from the Roots of Taraxacum coreanum |
title_sort | inositol derivatives and phenolic compounds from the roots of taraxacum coreanum |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152297/ https://www.ncbi.nlm.nih.gov/pubmed/28805750 http://dx.doi.org/10.3390/molecules22081349 |
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