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Inositol Derivatives and Phenolic Compounds from the Roots of Taraxacum coreanum

In this study, the characterization of chemical constituents and biological activity of the roots of Taraxacum coreanum (Asteraceae) was attempted. Phytochemical investigation of the roots of T. coreanum led to the isolation of two new inositol derivatives, taraxinositols A (1) and B (2), and a new...

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Autores principales: Mo, Eun Jin, Ahn, Jong Hoon, Jo, Yang Hee, Kim, Seon Beom, Hwang, Bang Yeon, Lee, Mi Kyeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152297/
https://www.ncbi.nlm.nih.gov/pubmed/28805750
http://dx.doi.org/10.3390/molecules22081349
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author Mo, Eun Jin
Ahn, Jong Hoon
Jo, Yang Hee
Kim, Seon Beom
Hwang, Bang Yeon
Lee, Mi Kyeong
author_facet Mo, Eun Jin
Ahn, Jong Hoon
Jo, Yang Hee
Kim, Seon Beom
Hwang, Bang Yeon
Lee, Mi Kyeong
author_sort Mo, Eun Jin
collection PubMed
description In this study, the characterization of chemical constituents and biological activity of the roots of Taraxacum coreanum (Asteraceae) was attempted. Phytochemical investigation of the roots of T. coreanum led to the isolation of two new inositol derivatives, taraxinositols A (1) and B (2), and a new phenolic compound, taraxinol (16), together with twenty known compounds including four inositol derivatives, neo-inositol-1,4-bis (4-hydroxybenzeneacetate) (3), chiro-inositol-1,5-bis(4- hydroxybenzeneacetate) (4), chiro-inositol-2,3-bis (4-hydroxybenzeneacetate) (5) and chiro-inositol- 1,2,3-tris (4-hydroxybenzeneacetate) (6), nine phenolic compounds: p-hydroxybenzaldehyde (7), vanillin (8), syringaldehyde (9), vanillic acid (10), 4-methoxyphenylacetic acid (11), 4-hydroxy- phenylacetic acid methyl ester (12), optivanin (13), isoferulic acid (14) and dihydroconiferyl alcohol (15), four coumarins: nodakenetin (17), decursinol (18), prangol (19) and isobyakangelicin (20), and three lignans: syringaresinol-4′-O-β-d-glucoside (21), syringaresinol (22), and pinoresinol (23). The structures of isolated compounds were determined on the basis of spectroscopic analysis. Among the isolated compounds, vanillic acid, isoferulic acid and syringaresinol showed radical scavenging activity with IC(50) values ranging from 30.4 to 75.2 μM.
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spelling pubmed-61522972018-11-13 Inositol Derivatives and Phenolic Compounds from the Roots of Taraxacum coreanum Mo, Eun Jin Ahn, Jong Hoon Jo, Yang Hee Kim, Seon Beom Hwang, Bang Yeon Lee, Mi Kyeong Molecules Article In this study, the characterization of chemical constituents and biological activity of the roots of Taraxacum coreanum (Asteraceae) was attempted. Phytochemical investigation of the roots of T. coreanum led to the isolation of two new inositol derivatives, taraxinositols A (1) and B (2), and a new phenolic compound, taraxinol (16), together with twenty known compounds including four inositol derivatives, neo-inositol-1,4-bis (4-hydroxybenzeneacetate) (3), chiro-inositol-1,5-bis(4- hydroxybenzeneacetate) (4), chiro-inositol-2,3-bis (4-hydroxybenzeneacetate) (5) and chiro-inositol- 1,2,3-tris (4-hydroxybenzeneacetate) (6), nine phenolic compounds: p-hydroxybenzaldehyde (7), vanillin (8), syringaldehyde (9), vanillic acid (10), 4-methoxyphenylacetic acid (11), 4-hydroxy- phenylacetic acid methyl ester (12), optivanin (13), isoferulic acid (14) and dihydroconiferyl alcohol (15), four coumarins: nodakenetin (17), decursinol (18), prangol (19) and isobyakangelicin (20), and three lignans: syringaresinol-4′-O-β-d-glucoside (21), syringaresinol (22), and pinoresinol (23). The structures of isolated compounds were determined on the basis of spectroscopic analysis. Among the isolated compounds, vanillic acid, isoferulic acid and syringaresinol showed radical scavenging activity with IC(50) values ranging from 30.4 to 75.2 μM. MDPI 2017-08-14 /pmc/articles/PMC6152297/ /pubmed/28805750 http://dx.doi.org/10.3390/molecules22081349 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mo, Eun Jin
Ahn, Jong Hoon
Jo, Yang Hee
Kim, Seon Beom
Hwang, Bang Yeon
Lee, Mi Kyeong
Inositol Derivatives and Phenolic Compounds from the Roots of Taraxacum coreanum
title Inositol Derivatives and Phenolic Compounds from the Roots of Taraxacum coreanum
title_full Inositol Derivatives and Phenolic Compounds from the Roots of Taraxacum coreanum
title_fullStr Inositol Derivatives and Phenolic Compounds from the Roots of Taraxacum coreanum
title_full_unstemmed Inositol Derivatives and Phenolic Compounds from the Roots of Taraxacum coreanum
title_short Inositol Derivatives and Phenolic Compounds from the Roots of Taraxacum coreanum
title_sort inositol derivatives and phenolic compounds from the roots of taraxacum coreanum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152297/
https://www.ncbi.nlm.nih.gov/pubmed/28805750
http://dx.doi.org/10.3390/molecules22081349
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