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Recent Progress in Nanomaterial-Based Electrochemical Biosensors for Cancer Biomarkers: A Review

This article reviews recent progress in the development of nanomaterial-based electrochemical biosensors for cancer biomarkers. Because of their high electrical conductivity, high affinity to biomolecules, and high surface area-to-weight ratios, nanomaterials, including metal nanoparticles, carbon n...

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Detalles Bibliográficos
Autores principales: Wang, Baozhen, Akiba, Uichi, Anzai, Jun-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152304/
https://www.ncbi.nlm.nih.gov/pubmed/28672780
http://dx.doi.org/10.3390/molecules22071048
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author Wang, Baozhen
Akiba, Uichi
Anzai, Jun-ichi
author_facet Wang, Baozhen
Akiba, Uichi
Anzai, Jun-ichi
author_sort Wang, Baozhen
collection PubMed
description This article reviews recent progress in the development of nanomaterial-based electrochemical biosensors for cancer biomarkers. Because of their high electrical conductivity, high affinity to biomolecules, and high surface area-to-weight ratios, nanomaterials, including metal nanoparticles, carbon nanotubes, and graphene, have been used for fabricating electrochemical biosensors. Electrodes are often coated with nanomaterials to increase the effective surface area of the electrodes and immobilize a large number of biomolecules such as enzymes and antibodies. Alternatively, nanomaterials are used as signaling labels for increasing the output signals of cancer biomarker sensors, in which nanomaterials are conjugated with secondary antibodies and redox compounds. According to this strategy, a variety of biosensors have been developed for detecting cancer biomarkers. Recent studies show that using nanomaterials is highly advantageous in preparing high-performance biosensors for detecting lower levels of cancer biomarkers. This review focuses mainly on the protocols for using nanomaterials to construct cancer biomarker sensors and the performance characteristics of the sensors. Recent trends in the development of cancer biomarker sensors are discussed according to the nanomaterials used.
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spelling pubmed-61523042018-11-13 Recent Progress in Nanomaterial-Based Electrochemical Biosensors for Cancer Biomarkers: A Review Wang, Baozhen Akiba, Uichi Anzai, Jun-ichi Molecules Review This article reviews recent progress in the development of nanomaterial-based electrochemical biosensors for cancer biomarkers. Because of their high electrical conductivity, high affinity to biomolecules, and high surface area-to-weight ratios, nanomaterials, including metal nanoparticles, carbon nanotubes, and graphene, have been used for fabricating electrochemical biosensors. Electrodes are often coated with nanomaterials to increase the effective surface area of the electrodes and immobilize a large number of biomolecules such as enzymes and antibodies. Alternatively, nanomaterials are used as signaling labels for increasing the output signals of cancer biomarker sensors, in which nanomaterials are conjugated with secondary antibodies and redox compounds. According to this strategy, a variety of biosensors have been developed for detecting cancer biomarkers. Recent studies show that using nanomaterials is highly advantageous in preparing high-performance biosensors for detecting lower levels of cancer biomarkers. This review focuses mainly on the protocols for using nanomaterials to construct cancer biomarker sensors and the performance characteristics of the sensors. Recent trends in the development of cancer biomarker sensors are discussed according to the nanomaterials used. MDPI 2017-06-24 /pmc/articles/PMC6152304/ /pubmed/28672780 http://dx.doi.org/10.3390/molecules22071048 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wang, Baozhen
Akiba, Uichi
Anzai, Jun-ichi
Recent Progress in Nanomaterial-Based Electrochemical Biosensors for Cancer Biomarkers: A Review
title Recent Progress in Nanomaterial-Based Electrochemical Biosensors for Cancer Biomarkers: A Review
title_full Recent Progress in Nanomaterial-Based Electrochemical Biosensors for Cancer Biomarkers: A Review
title_fullStr Recent Progress in Nanomaterial-Based Electrochemical Biosensors for Cancer Biomarkers: A Review
title_full_unstemmed Recent Progress in Nanomaterial-Based Electrochemical Biosensors for Cancer Biomarkers: A Review
title_short Recent Progress in Nanomaterial-Based Electrochemical Biosensors for Cancer Biomarkers: A Review
title_sort recent progress in nanomaterial-based electrochemical biosensors for cancer biomarkers: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152304/
https://www.ncbi.nlm.nih.gov/pubmed/28672780
http://dx.doi.org/10.3390/molecules22071048
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