Cargando…
Upregulation of Melanogenesis and Tyrosinase Activity: Potential Agents for Vitiligo
Melanin, the compound primarily responsible in humans for hair, eye and skin pigmentation, is produced by melanocytes through a complicated process called melanogenesis that is catalyzed by tyrosinase and other tyrosinase-related proteins. The abnormal loss of melanin causes dermatological problems...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152334/ https://www.ncbi.nlm.nih.gov/pubmed/28777326 http://dx.doi.org/10.3390/molecules22081303 |
_version_ | 1783357346714484736 |
---|---|
author | Niu, Chao Aisa, Haji A. |
author_facet | Niu, Chao Aisa, Haji A. |
author_sort | Niu, Chao |
collection | PubMed |
description | Melanin, the compound primarily responsible in humans for hair, eye and skin pigmentation, is produced by melanocytes through a complicated process called melanogenesis that is catalyzed by tyrosinase and other tyrosinase-related proteins. The abnormal loss of melanin causes dermatological problems such as vitiligo. Hence the regulation of melanogenesis and tyrosinase activity is very important for treating hypopigmentary disorders. Many melanogenesis stimulators have been discovered during the past decade. This article reviews recent advances in research on extracts and active ingredients of plants, synthesized compounds with stimulating effect on melanin synthesis and tyrosinase activity, as well as their influence on the expression of related proteins and possible signaling pathways for the design and development of novel anti-vitiligo agents. |
format | Online Article Text |
id | pubmed-6152334 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61523342018-11-13 Upregulation of Melanogenesis and Tyrosinase Activity: Potential Agents for Vitiligo Niu, Chao Aisa, Haji A. Molecules Review Melanin, the compound primarily responsible in humans for hair, eye and skin pigmentation, is produced by melanocytes through a complicated process called melanogenesis that is catalyzed by tyrosinase and other tyrosinase-related proteins. The abnormal loss of melanin causes dermatological problems such as vitiligo. Hence the regulation of melanogenesis and tyrosinase activity is very important for treating hypopigmentary disorders. Many melanogenesis stimulators have been discovered during the past decade. This article reviews recent advances in research on extracts and active ingredients of plants, synthesized compounds with stimulating effect on melanin synthesis and tyrosinase activity, as well as their influence on the expression of related proteins and possible signaling pathways for the design and development of novel anti-vitiligo agents. MDPI 2017-08-04 /pmc/articles/PMC6152334/ /pubmed/28777326 http://dx.doi.org/10.3390/molecules22081303 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Niu, Chao Aisa, Haji A. Upregulation of Melanogenesis and Tyrosinase Activity: Potential Agents for Vitiligo |
title | Upregulation of Melanogenesis and Tyrosinase Activity: Potential Agents for Vitiligo |
title_full | Upregulation of Melanogenesis and Tyrosinase Activity: Potential Agents for Vitiligo |
title_fullStr | Upregulation of Melanogenesis and Tyrosinase Activity: Potential Agents for Vitiligo |
title_full_unstemmed | Upregulation of Melanogenesis and Tyrosinase Activity: Potential Agents for Vitiligo |
title_short | Upregulation of Melanogenesis and Tyrosinase Activity: Potential Agents for Vitiligo |
title_sort | upregulation of melanogenesis and tyrosinase activity: potential agents for vitiligo |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152334/ https://www.ncbi.nlm.nih.gov/pubmed/28777326 http://dx.doi.org/10.3390/molecules22081303 |
work_keys_str_mv | AT niuchao upregulationofmelanogenesisandtyrosinaseactivitypotentialagentsforvitiligo AT aisahajia upregulationofmelanogenesisandtyrosinaseactivitypotentialagentsforvitiligo |