Five New Phenolic Compounds with Antioxidant Activities from the Medicinal Insect Blaps rynchopetera

Five new phenolic compounds rynchopeterines A–E (1–5), in addition to thirteen known phenolics, were isolated from Blaps rynchopetera Fairmaire, a kind of medicinal insect utilized by the Yi Nationality in Yunnan Province of China. Their structures were established on the basis of extensive spectros...

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Autores principales: Xiao, Huai, Yin, Tian-Peng, Dong, Jian-Wei, Wu, Xiu-Mei, Luo, Qing, Luo, Jian-Rong, Cai, Le, Ding, Zhong-Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152337/
https://www.ncbi.nlm.nih.gov/pubmed/28777311
http://dx.doi.org/10.3390/molecules22081301
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author Xiao, Huai
Yin, Tian-Peng
Dong, Jian-Wei
Wu, Xiu-Mei
Luo, Qing
Luo, Jian-Rong
Cai, Le
Ding, Zhong-Tao
author_facet Xiao, Huai
Yin, Tian-Peng
Dong, Jian-Wei
Wu, Xiu-Mei
Luo, Qing
Luo, Jian-Rong
Cai, Le
Ding, Zhong-Tao
author_sort Xiao, Huai
collection PubMed
description Five new phenolic compounds rynchopeterines A–E (1–5), in addition to thirteen known phenolics, were isolated from Blaps rynchopetera Fairmaire, a kind of medicinal insect utilized by the Yi Nationality in Yunnan Province of China. Their structures were established on the basis of extensive spectroscopic analyses (1D and 2D NMR, HR-MS, IR) along with calculated electronic circular dichroism method. Rynchopeterines A–E (1–4) exhibited significant antioxidant activities with IC(50) values of 7.67–12.3 μg/mL measured by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Besides, rynchopeterines B (2) and C (3) showed mild cytotoxicity against tumor cell Caco-2 and A549.
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spelling pubmed-61523372018-11-13 Five New Phenolic Compounds with Antioxidant Activities from the Medicinal Insect Blaps rynchopetera Xiao, Huai Yin, Tian-Peng Dong, Jian-Wei Wu, Xiu-Mei Luo, Qing Luo, Jian-Rong Cai, Le Ding, Zhong-Tao Molecules Article Five new phenolic compounds rynchopeterines A–E (1–5), in addition to thirteen known phenolics, were isolated from Blaps rynchopetera Fairmaire, a kind of medicinal insect utilized by the Yi Nationality in Yunnan Province of China. Their structures were established on the basis of extensive spectroscopic analyses (1D and 2D NMR, HR-MS, IR) along with calculated electronic circular dichroism method. Rynchopeterines A–E (1–4) exhibited significant antioxidant activities with IC(50) values of 7.67–12.3 μg/mL measured by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Besides, rynchopeterines B (2) and C (3) showed mild cytotoxicity against tumor cell Caco-2 and A549. MDPI 2017-08-04 /pmc/articles/PMC6152337/ /pubmed/28777311 http://dx.doi.org/10.3390/molecules22081301 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xiao, Huai
Yin, Tian-Peng
Dong, Jian-Wei
Wu, Xiu-Mei
Luo, Qing
Luo, Jian-Rong
Cai, Le
Ding, Zhong-Tao
Five New Phenolic Compounds with Antioxidant Activities from the Medicinal Insect Blaps rynchopetera
title Five New Phenolic Compounds with Antioxidant Activities from the Medicinal Insect Blaps rynchopetera
title_full Five New Phenolic Compounds with Antioxidant Activities from the Medicinal Insect Blaps rynchopetera
title_fullStr Five New Phenolic Compounds with Antioxidant Activities from the Medicinal Insect Blaps rynchopetera
title_full_unstemmed Five New Phenolic Compounds with Antioxidant Activities from the Medicinal Insect Blaps rynchopetera
title_short Five New Phenolic Compounds with Antioxidant Activities from the Medicinal Insect Blaps rynchopetera
title_sort five new phenolic compounds with antioxidant activities from the medicinal insect blaps rynchopetera
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152337/
https://www.ncbi.nlm.nih.gov/pubmed/28777311
http://dx.doi.org/10.3390/molecules22081301
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