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Structure-Activity Relationships of Acyclic Selenopurine Nucleosides as Antiviral Agents

A series of acyclic selenopurine nucleosides 3a–f and 4a–g were synthesized based on the bioisosteric rationale between oxygen and selenium, and then evaluated for antiviral activity. Among the compounds tested, seleno-acyclovir (4a) exhibited the most potent anti-herpes simplex virus (HSV)-1 (EC(50...

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Detalles Bibliográficos
Autores principales:	Sahu, Pramod K., Umme, Tamima, Yu, Jinha, Kim, Gyudong, Qu, Shuhao, Naik, Siddhi D., Jeong, Lak Shin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152377/ https://www.ncbi.nlm.nih.gov/pubmed/28704950 http://dx.doi.org/10.3390/molecules22071167

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