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A case of hepato-biliary infection secondary to cryptosporidium in a patient on tacrolimus
INTRODUCTION. Cryptosporidium infection is known to cause hepato-biliary involvement, mainly in association with T-cell immune deficiency. Hepato-biliary involvement in association with milder immunosuppression is less well described. We describe the first case, to our knowledge, of Cryptosporidium...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Microbiology Society
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152403/ https://www.ncbi.nlm.nih.gov/pubmed/30323935 http://dx.doi.org/10.1099/jmmcr.0.005159 |
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author | Gupta, Sajal Johnson, Alison Meyrick, Simon Davies, Angharad P. Chalmers, R. |
author_facet | Gupta, Sajal Johnson, Alison Meyrick, Simon Davies, Angharad P. Chalmers, R. |
author_sort | Gupta, Sajal |
collection | PubMed |
description | INTRODUCTION. Cryptosporidium infection is known to cause hepato-biliary involvement, mainly in association with T-cell immune deficiency. Hepato-biliary involvement in association with milder immunosuppression is less well described. We describe the first case, to our knowledge, of Cryptosporidium hominis hepato-biliary infection associated with tacrolimus in a patient with nephrotic syndrome. CASE PRESENTATION. A 14 year old girl who had been on tacrolimus for nephrotic syndrome presented with diarrhea due to C. hominis. Nineteen days after her initial presentation she attended hospital with abdominal pain and deranged liver function tests. An ultrasound scan showed a thickened gall bladder. Her symptoms settled and her liver function tests returned to normal after treatment with nitazoxanide. CONCLUSION. Cryptosporidium should be considered in the differential diagnosis of both diarrhea and hepato-biliary symptoms and abnormal liver function tests, even in the presence of relatively mild immunosuppression. Nitazoxanide was an effective treatment in this case. |
format | Online Article Text |
id | pubmed-6152403 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Microbiology Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-61524032018-10-15 A case of hepato-biliary infection secondary to cryptosporidium in a patient on tacrolimus Gupta, Sajal Johnson, Alison Meyrick, Simon Davies, Angharad P. Chalmers, R. JMM Case Rep Case Report INTRODUCTION. Cryptosporidium infection is known to cause hepato-biliary involvement, mainly in association with T-cell immune deficiency. Hepato-biliary involvement in association with milder immunosuppression is less well described. We describe the first case, to our knowledge, of Cryptosporidium hominis hepato-biliary infection associated with tacrolimus in a patient with nephrotic syndrome. CASE PRESENTATION. A 14 year old girl who had been on tacrolimus for nephrotic syndrome presented with diarrhea due to C. hominis. Nineteen days after her initial presentation she attended hospital with abdominal pain and deranged liver function tests. An ultrasound scan showed a thickened gall bladder. Her symptoms settled and her liver function tests returned to normal after treatment with nitazoxanide. CONCLUSION. Cryptosporidium should be considered in the differential diagnosis of both diarrhea and hepato-biliary symptoms and abnormal liver function tests, even in the presence of relatively mild immunosuppression. Nitazoxanide was an effective treatment in this case. Microbiology Society 2018-07-20 /pmc/articles/PMC6152403/ /pubmed/30323935 http://dx.doi.org/10.1099/jmmcr.0.005159 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Gupta, Sajal Johnson, Alison Meyrick, Simon Davies, Angharad P. Chalmers, R. A case of hepato-biliary infection secondary to cryptosporidium in a patient on tacrolimus |
title | A case of hepato-biliary infection secondary to cryptosporidium in a patient on tacrolimus |
title_full | A case of hepato-biliary infection secondary to cryptosporidium in a patient on tacrolimus |
title_fullStr | A case of hepato-biliary infection secondary to cryptosporidium in a patient on tacrolimus |
title_full_unstemmed | A case of hepato-biliary infection secondary to cryptosporidium in a patient on tacrolimus |
title_short | A case of hepato-biliary infection secondary to cryptosporidium in a patient on tacrolimus |
title_sort | case of hepato-biliary infection secondary to cryptosporidium in a patient on tacrolimus |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152403/ https://www.ncbi.nlm.nih.gov/pubmed/30323935 http://dx.doi.org/10.1099/jmmcr.0.005159 |
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