Cargando…

Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study

OBJECTIVES: To examine temporal trend in uptake of seasonal influenza vaccine (SIV) in the UK and explore disease and demographic factors associated with vaccination. METHODS: From the Clinical Practice Research Datalink, 32 751 people with auto-immune rheumatic diseases prescribed DMARDs between 20...

Descripción completa

Detalles Bibliográficos
Autores principales: Nakafero, Georgina, Grainge, Matthew J, Myles, Puja R, Mallen, Christian D, Zhang, Weiya, Doherty, Michael, Nguyen-Van-Tam, Jonathan S, Abhishek, Abhishek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152422/
https://www.ncbi.nlm.nih.gov/pubmed/29901743
http://dx.doi.org/10.1093/rheumatology/key156
_version_ 1783357364548665344
author Nakafero, Georgina
Grainge, Matthew J
Myles, Puja R
Mallen, Christian D
Zhang, Weiya
Doherty, Michael
Nguyen-Van-Tam, Jonathan S
Abhishek, Abhishek
author_facet Nakafero, Georgina
Grainge, Matthew J
Myles, Puja R
Mallen, Christian D
Zhang, Weiya
Doherty, Michael
Nguyen-Van-Tam, Jonathan S
Abhishek, Abhishek
author_sort Nakafero, Georgina
collection PubMed
description OBJECTIVES: To examine temporal trend in uptake of seasonal influenza vaccine (SIV) in the UK and explore disease and demographic factors associated with vaccination. METHODS: From the Clinical Practice Research Datalink, 32 751 people with auto-immune rheumatic diseases prescribed DMARDs between 2006 and 2016 were identified. The proportion vaccinated between 1 September of one year and 31 March of the next year was calculated and stratified by age, other indications for vaccination, auto-immune rheumatic diseases type and number of DMARDs prescribed. Stata and Joinpoint regression programs were used. RESULTS: SIV uptake was high in those aged ⩾65 years (82.3 and 80.7% in 2006–07 and 2015–16, respectively). It was significantly lower in other age groups, but improved over time with 51.9 and 61.9% in the 45–64 year age group, and 32.3 and 50.1% in the <45 year age group being vaccinated in 2006–07 and 2015–16, respectively. While 64.9% of the vaccinations in those ⩾65 years old occurred by 3 November, in time to mount a protective immune response before the influenza activity becomes substantial in the UK, only 38.9% in the 45–64 year and 26.2% in the <45 year age group without any other reason for vaccination received SIV by this date. Women, those with additional indications for vaccination, on multiple DMARDs and with SLE were more likely to be vaccinated. CONCLUSION: SIV uptake is low in the under 65s, and the majority of them are not vaccinated in time. Additional effort is required to promote timely uptake of SIV in this population.
format Online
Article
Text
id pubmed-6152422
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-61524222018-09-27 Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study Nakafero, Georgina Grainge, Matthew J Myles, Puja R Mallen, Christian D Zhang, Weiya Doherty, Michael Nguyen-Van-Tam, Jonathan S Abhishek, Abhishek Rheumatology (Oxford) Clinical Science OBJECTIVES: To examine temporal trend in uptake of seasonal influenza vaccine (SIV) in the UK and explore disease and demographic factors associated with vaccination. METHODS: From the Clinical Practice Research Datalink, 32 751 people with auto-immune rheumatic diseases prescribed DMARDs between 2006 and 2016 were identified. The proportion vaccinated between 1 September of one year and 31 March of the next year was calculated and stratified by age, other indications for vaccination, auto-immune rheumatic diseases type and number of DMARDs prescribed. Stata and Joinpoint regression programs were used. RESULTS: SIV uptake was high in those aged ⩾65 years (82.3 and 80.7% in 2006–07 and 2015–16, respectively). It was significantly lower in other age groups, but improved over time with 51.9 and 61.9% in the 45–64 year age group, and 32.3 and 50.1% in the <45 year age group being vaccinated in 2006–07 and 2015–16, respectively. While 64.9% of the vaccinations in those ⩾65 years old occurred by 3 November, in time to mount a protective immune response before the influenza activity becomes substantial in the UK, only 38.9% in the 45–64 year and 26.2% in the <45 year age group without any other reason for vaccination received SIV by this date. Women, those with additional indications for vaccination, on multiple DMARDs and with SLE were more likely to be vaccinated. CONCLUSION: SIV uptake is low in the under 65s, and the majority of them are not vaccinated in time. Additional effort is required to promote timely uptake of SIV in this population. Oxford University Press 2018-10 2018-06-12 /pmc/articles/PMC6152422/ /pubmed/29901743 http://dx.doi.org/10.1093/rheumatology/key156 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of the British Society for Rheumatology. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Science
Nakafero, Georgina
Grainge, Matthew J
Myles, Puja R
Mallen, Christian D
Zhang, Weiya
Doherty, Michael
Nguyen-Van-Tam, Jonathan S
Abhishek, Abhishek
Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study
title Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study
title_full Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study
title_fullStr Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study
title_full_unstemmed Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study
title_short Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study
title_sort predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the uk: a nationwide prospective cohort study
topic Clinical Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152422/
https://www.ncbi.nlm.nih.gov/pubmed/29901743
http://dx.doi.org/10.1093/rheumatology/key156
work_keys_str_mv AT nakaferogeorgina predictorsandtemporaltrendoffluvaccinationinautoimmunerheumaticdiseasesintheukanationwideprospectivecohortstudy
AT graingematthewj predictorsandtemporaltrendoffluvaccinationinautoimmunerheumaticdiseasesintheukanationwideprospectivecohortstudy
AT mylespujar predictorsandtemporaltrendoffluvaccinationinautoimmunerheumaticdiseasesintheukanationwideprospectivecohortstudy
AT mallenchristiand predictorsandtemporaltrendoffluvaccinationinautoimmunerheumaticdiseasesintheukanationwideprospectivecohortstudy
AT zhangweiya predictorsandtemporaltrendoffluvaccinationinautoimmunerheumaticdiseasesintheukanationwideprospectivecohortstudy
AT dohertymichael predictorsandtemporaltrendoffluvaccinationinautoimmunerheumaticdiseasesintheukanationwideprospectivecohortstudy
AT nguyenvantamjonathans predictorsandtemporaltrendoffluvaccinationinautoimmunerheumaticdiseasesintheukanationwideprospectivecohortstudy
AT abhishekabhishek predictorsandtemporaltrendoffluvaccinationinautoimmunerheumaticdiseasesintheukanationwideprospectivecohortstudy