Development of a Target cell-Biologics-Effector cell (TBE) complex-based cell killing model to characterize target cell depletion by T cell redirecting bispecific agents

T-cell redirecting bispecific antibodies (bsAbs) or antibody-derived agents that combine tumor antigen recognition with CD3-mediated T cell recruitment are highly potent tumor-killing molecules. Despite the tremendous progress achieved in the last decade, development of such bsAbs still faces many c...

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Detalles Bibliográficos
Autores principales: Jiang, Xiling, Chen, Xi, Carpenter, Thomas J., Wang, Jun, Zhou, Rebecca, Davis, Hugh M., Heald, Donald L., Wang, Weirong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152432/
https://www.ncbi.nlm.nih.gov/pubmed/29985776
http://dx.doi.org/10.1080/19420862.2018.1480299

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