COPD-Type lung inflammation promotes K-ras mutant lung cancer through epithelial HIF-1α mediated tumor angiogenesis and proliferation

Chronic obstructive pulmonary disease (COPD), an inflammatory disease of the lung, is an independent risk factor for lung cancer. Lung tissues obtained from human smokers with COPD and lung cancer demonstrate hypoxia and up-regulated hypoxia inducible factor-1 (HIF-1). HIF-1 activation is the centra...

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Detalles Bibliográficos
Autores principales: De la Garza, Maria Miguelina, Cumpian, Amber M., Daliri, Soudabeh, Castro-Pando, Susana, Umer, Misha, Gong, Lei, Khosravi, Nasim, Caetano, Mauricio S., Ramos-Castañeda, Marco, Flores, Alejandra Garza, Beltran, Evelyn C., Tran, Hai T., Tuvim, Michael J., Ostrin, Edwin J., Dickey, Burton F., Evans, Christopher M., Moghaddam, Seyed Javad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152479/
https://www.ncbi.nlm.nih.gov/pubmed/30250643
http://dx.doi.org/10.18632/oncotarget.26030

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